Kikuchi K, Miyakawa H, Abe K, Fujikawa H, Horiuchi T, Nagai K, Kako M
Fourth Department of Internal Medicine, Teikyo University School of Medicine, Kanagawa, Japan.
Dig Dis Sci. 2000 Jan;45(1):160-5. doi: 10.1023/a:1005434015863.
We reported here an adult patient with vanishing bile duct syndrome due to chronic EBV infection. A 22-year-old male was admitted to a nearby hospital complaining of a sore throat and jaundice. He received a high dose of prednisolone for bile stasis of acute viral hepatitis. However, the hepatitis did not improve, and he was transferred to our hospital. He had exhibited jaundice for one year as well as hemophagocytic syndrome and intestinal perforation. Subtotal intestinal resection was successfully performed. Three follow-up biopsied liver specimens indicated vanishing bile duct syndrome. Positive results of EBV-DNA in his serum and mRNA of EBV by in situ hybridization of his liver indicated that massive doses of prednisolone caused chronic EBV infection and vanishing bile duct syndrome.
我们在此报告一例因慢性EB病毒感染导致消失性胆管综合征的成年患者。一名22岁男性因咽痛和黄疸入住附近医院。他因急性病毒性肝炎胆汁淤积接受了大剂量泼尼松龙治疗。然而，肝炎并未改善，随后他被转至我院。他出现黄疸已一年，同时伴有噬血细胞综合征和肠穿孔。成功实施了部分肠切除术。三次随访的肝脏活检标本显示为消失性胆管综合征。他血清中EB病毒DNA阳性，肝脏原位杂交显示EB病毒mRNA阳性，表明大剂量泼尼松龙导致了慢性EB病毒感染和消失性胆管综合征。
