Vincent A, Lily O, Palace J
Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
J Neuroimmunol. 1999 Dec;100(1-2):169-80. doi: 10.1016/s0165-5728(99)00210-6.
Autoantibodies to acetylcholine receptors and to voltage-gated calcium and potassium channels are thought to be pathogenic in three peripheral neurological disorders: myasthenia gravis, the Lambert Eaton syndrome and acquired neuromyotonia. However, evidence for the role of antibodies in conditions involving the central nervous system, is scanty or unclear. This review describes the ways in which the roles of autoantibodies have been defined in the peripheral diseases, and discusses the more controversial evidence for involvement of autoantibodies in some central disorders such as multiple sclerosis.
重症肌无力、兰伯特-伊顿综合征和获得性神经性肌强直。然而，关于抗体在涉及中枢神经系统疾病中的作用的证据却很少或不明确。这篇综述描述了在外周疾病中确定自身抗体作用的方式，并讨论了自身抗体参与某些中枢疾病（如多发性硬化症）的更具争议性的证据。
