• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Immunological evidence for the co-existence of the Lambert-Eaton myasthenic syndrome and myasthenia gravis in two patients.两名患者中兰伯特-伊顿肌无力综合征与重症肌无力共存的免疫学证据。
J Neurol Neurosurg Psychiatry. 1991 May;54(5):452-3. doi: 10.1136/jnnp.54.5.452.
2
Myasthenia gravis Lambert-Eaton overlap syndrome.重症肌无力-兰伯特-伊顿重叠综合征
Muscle Nerve. 2016 Jan;53(1):20-6. doi: 10.1002/mus.24921. Epub 2015 Nov 26.
3
[A case of myasthenia gravis with coexistence of anti-acetylcholine receptor antibodies and anti-P/Q-type VGCC antibodies].1例重症肌无力合并抗乙酰胆碱受体抗体和抗P/Q型电压门控性钙通道抗体阳性病例
Rinsho Shinkeigaku. 2024 Apr 24;64(4):292-295. doi: 10.5692/clinicalneurol.cn-001945. Epub 2024 Mar 20.
4
Oculomotor signs in Lambert-Eaton myasthenic syndrome-coincidence with myasthenia gravis.兰伯特-伊顿肌无力综合征中的动眼神经体征——与重症肌无力的巧合
Ann Neurol. 2003 Jul;54(1):135-6; author reply 136-7. doi: 10.1002/ana.10640.
5
[Antibodies to acetylcholine receptor in patients with different clinical forms of myasthenia and Lambert-Eaton myasthenic syndrome].
Zh Nevrol Psikhiatr Im S S Korsakova. 2006;106(1):53-5.
6
Incidence of serum anti-P/O-type and anti-N-type calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome.兰伯特-伊顿肌无力综合征患者血清抗P/O型和抗N型钙通道自身抗体的发生率。
J Neurol Sci. 1997 Mar 20;147(1):35-42. doi: 10.1016/s0022-510x(96)05303-8.
7
[Immunologic aspects of disorders of neuromuscular transmission. 2. Experimental autoimmune myasthenia gravis and the Lambert-Eaton myasthenic syndrome].[神经肌肉传递障碍的免疫学方面。2. 实验性自身免疫性重症肌无力和兰伯特-伊顿肌无力综合征]
Lijec Vjesn. 1994 May-Jun;116(5-6):158-61.
8
[Immunopathogenesis of myasthenia gravis and the Lambert-Eaton myasthenic syndrome].[重症肌无力和兰伯特-伊顿肌无力综合征的免疫发病机制]
Bratisl Lek Listy. 1997 Apr;98(4):217-20.
9
Acetylcholine receptor antibodies in the Lambert-Eaton myasthenic syndrome.兰伯特-伊顿肌无力综合征中的乙酰胆碱受体抗体。
Neurology. 1998 Feb;50(2):470-5. doi: 10.1212/wnl.50.2.470.
10
[Autoimmune myasthenia and Lambert-Eaton myasthenic syndrome. Physiopathologic concepts].[自身免疫性重症肌无力和兰伯特-伊顿肌无力综合征。病理生理概念]
Ann Med Interne (Paris). 1989;140(6):462-6.

引用本文的文献

1
Simulations of active zone structure and function at mammalian NMJs predict that loss of calcium channels alone is not sufficient to replicate LEMS effects.哺乳动物 NMJ 上的活性区结构和功能模拟预测，仅丧失钙通道不足以复制 LEMS 的作用。
J Neurophysiol. 2023 May 1;129(5):1259-1277. doi: 10.1152/jn.00404.2022. Epub 2023 Apr 19.
2
Lambert-Eaton myasthenic syndrome (LEMS): a rare autoimmune presynaptic disorder often associated with cancer. Lambert-Eaton 肌无力综合征（LEMS）：一种罕见的自身免疫性突触前疾病，常与癌症相关。
J Neurol. 2017 Sep;264(9):1854-1863. doi: 10.1007/s00415-017-8541-9. Epub 2017 Jun 12.
3
Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system.绘制自身抗原表位：对自身抗体相关神经系统疾病的分子见解
J Neuroinflammation. 2016 Aug 30;13(1):219. doi: 10.1186/s12974-016-0678-4.
4
A case of lambert-eaton myasthenic syndrome with small-cell lung cancer and transient increase in anti-acetylcholine-receptor-binding antibody titer.一例伴有小细胞肺癌的 Lambert-Eaton 肌无力综合征及乙酰胆碱受体结合抗体滴度的一过性升高。
J Clin Neurol. 2012 Dec;8(4):305-7. doi: 10.3988/jcn.2012.8.4.305. Epub 2012 Dec 21.
5
A patient with coexisting myasthenia gravis and lambert-eaton myasthenic syndrome.同时患有重症肌无力和 Lambert-Eaton 肌无力综合征的患者。
J Clin Neurol. 2012 Sep;8(3):235-7. doi: 10.3988/jcn.2012.8.3.235. Epub 2012 Sep 27.
6
An interesting collection of paraneoplastic syndromes in a patient with a malignant thymoma.一名恶性胸腺瘤患者出现的一组有趣的副肿瘤综合征。
BMJ Case Rep. 2012 Jul 3;2012:bcr0220125790. doi: 10.1136/bcr.02.2012.5790.
7
Autonomic dysfunction in Lambert-Eaton myasthenic syndrome.兰伯特-伊顿肌无力综合征中的自主神经功能障碍。
Clin Auton Res. 2001 Jun;11(3):145-54. doi: 10.1007/BF02329922.

本文引用的文献

1
Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis.重症肌无力疾病异质性的临床、病理、HLA抗原及免疫学证据
Brain. 1980 Sep;103(3):579-601. doi: 10.1093/brain/103.3.579.
2
Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays.乙酰胆碱受体抗体作为重症肌无力的诊断检测：153例确诊病例及2967次诊断检测的结果
J Neurol Neurosurg Psychiatry. 1985 Dec;48(12):1246-52. doi: 10.1136/jnnp.48.12.1246.
3
Increased frequency of IgG heavy chain marker Glm(2) and of HLA-B8 in Lambert-Eaton myasthenic syndrome with and without associated lung carcinoma.伴或不伴相关肺癌的兰伯特-伊顿肌无力综合征中IgG重链标记物Glm(2)及HLA-B8频率增加。
Hum Immunol. 1985 Sep;14(1):29-36. doi: 10.1016/0198-8859(85)90062-x.
4
Autoimmunity in neuromuscular disease.
Ann N Y Acad Sci. 1988;540:25-38. doi: 10.1111/j.1749-6632.1988.tb27048.x.
5
A neuromuscular transmission disorder: combined myasthenia gravis and Lambert Eaton syndrome in one patient.一种神经肌肉传递障碍：一名患者同时患有重症肌无力和兰伯特-伊顿综合征。
J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):880-2. doi: 10.1136/jnnp.51.6.880.
6
The Lambert-Eaton myasthenic syndrome. A review of 50 cases.兰伯特-伊顿肌无力综合征。50例病例回顾。
Brain. 1988 Jun;111 ( Pt 3):577-96. doi: 10.1093/brain/111.3.577.
7
Specificity of calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome.
Lancet. 1989 Sep 16;2(8664):640-3. doi: 10.1016/s0140-6736(89)90893-3.
8
Trial of low-dose aspirin plus dipyridamole versus anticoagulants for prevention of aortocoronary vein graft occlusion.小剂量阿司匹林加双嘧达莫与抗凝剂预防主动脉冠状动脉静脉移植闭塞的试验。
Lancet. 1989 Jul 1;2(8653):1-7. doi: 10.1016/s0140-6736(89)90253-5.
9
Autoantibodies bind solubilized calcium channel-omega-conotoxin complexes from small cell lung carcinoma: a diagnostic aid for Lambert-Eaton myasthenic syndrome.
Mayo Clin Proc. 1989 Dec;64(12):1498-504. doi: 10.1016/s0025-6196(12)65705-x.

两名患者中兰伯特-伊顿肌无力综合征与重症肌无力共存的免疫学证据。

Immunological evidence for the co-existence of the Lambert-Eaton myasthenic syndrome and myasthenia gravis in two patients.

作者信息

Newsom-Davis J, Leys K, Vincent A, Ferguson I, Modi G, Mills K

机构信息

Department of Neurology, Radcliffe Infirmary, University of Oxford, UK.

出版信息

J Neurol Neurosurg Psychiatry. 1991 May;54(5):452-3. doi: 10.1136/jnnp.54.5.452.

DOI:10.1136/jnnp.54.5.452
PMID:1650816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC488548/
Abstract

Two patients are described in whom a clinical and electromyographic diagnosis of the Lambert-Eaton myasthenic syndrome (LEMS) was made. Serum antibodies to voltage-gated calcium channels (VGCCs), the antigenic target in LEMS and to acetylcholine receptors (AChRs), the antigen in myasthenia gravis, were detected at raised titres in both cases, using radioimmunoassays based on 125I-omega-Conotoxin labelled VGCCs and 125I-alpha-Bungarotoxin labelled AChRs. These data provide immunological evidence for the coexistence of the two disorders in these patients.

摘要

本文描述了两名患者，他们经临床和肌电图诊断为兰伯特-伊顿肌无力综合征（LEMS）。使用基于125I-ω-芋螺毒素标记的电压门控钙通道（VGCCs）和125I-α-银环蛇毒素标记的乙酰胆碱受体（AChRs）的放射免疫分析法，在这两名患者中均检测到针对LEMS抗原靶点VGCCs和重症肌无力抗原AChRs的血清抗体，且滴度升高。这些数据为这两名患者中两种疾病共存提供了免疫学证据。