两名患者中兰伯特-伊顿肌无力综合征与重症肌无力共存的免疫学证据。
Immunological evidence for the co-existence of the Lambert-Eaton myasthenic syndrome and myasthenia gravis in two patients.
作者信息
Newsom-Davis J, Leys K, Vincent A, Ferguson I, Modi G, Mills K
机构信息
Department of Neurology, Radcliffe Infirmary, University of Oxford, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1991 May;54(5):452-3. doi: 10.1136/jnnp.54.5.452.
Abstract
Two patients are described in whom a clinical and electromyographic diagnosis of the Lambert-Eaton myasthenic syndrome (LEMS) was made. Serum antibodies to voltage-gated calcium channels (VGCCs), the antigenic target in LEMS and to acetylcholine receptors (AChRs), the antigen in myasthenia gravis, were detected at raised titres in both cases, using radioimmunoassays based on 125I-omega-Conotoxin labelled VGCCs and 125I-alpha-Bungarotoxin labelled AChRs. These data provide immunological evidence for the coexistence of the two disorders in these patients.
摘要
本文描述了两名患者，他们经临床和肌电图诊断为兰伯特-伊顿肌无力综合征（LEMS）。使用基于125I-ω-芋螺毒素标记的电压门控钙通道（VGCCs）和125I-α-银环蛇毒素标记的乙酰胆碱受体（AChRs）的放射免疫分析法，在这两名患者中均检测到针对LEMS抗原靶点VGCCs和重症肌无力抗原AChRs的血清抗体，且滴度升高。这些数据为这两名患者中两种疾病共存提供了免疫学证据。
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Immunological evidence for the co-existence of the Lambert-Eaton myasthenic syndrome and myasthenia gravis in two patients.两名患者中兰伯特-伊顿肌无力综合征与重症肌无力共存的免疫学证据。
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