Chen Y L, Chen Y H, Mak F L
Department of Psychiatry, University of Hong Kong, Queen Mary Hospital.
J Nerv Ment Dis. 2000 Feb;188(2):84-9. doi: 10.1097/00005053-200002000-00004.
This study examined neurological signs as familial vulnerability factors to schizophrenia. Fifteen Chinese schizophrenic patients, 21 of their nonpsychotic siblings, and 26 healthy volunteers, matched for age, sex, and education, were assessed by using the Cambridge Neurological Inventory. Results showed that patients and their siblings had significantly higher global neurological impairment than controls. The severity of motor coordination impairment of the siblings was in between patients and controls. This may suggest either patients have higher genetic vulnerability for the neurological abnormality and schizophrenia than their nonpsychotic siblings or the disease can further worsen the preexisting neurological deficit. Disinhibition signs were similar in patients and siblings, but significantly less in controls indicating its familial nature. Extrapyramidal and sensory integration signs were similar in siblings and controls, but significantly more severe in patients, suggesting nonfamilial abnormalities. In conclusion, these findings may imply different etiological origins for different subgroups of neurological signs.
本研究将神经学体征作为精神分裂症的家族易感性因素进行了考察。采用剑桥神经学量表对15名中国精神分裂症患者、21名他们未患精神病的兄弟姐妹以及26名年龄、性别和教育程度相匹配的健康志愿者进行了评估。结果显示，患者及其兄弟姐妹的整体神经功能损害显著高于对照组。兄弟姐妹的运动协调障碍严重程度介于患者和对照组之间。这可能表明，与未患精神病的兄弟姐妹相比，患者对神经异常和精神分裂症具有更高的遗传易感性，或者该疾病会进一步加重已有的神经功能缺损。患者及其兄弟姐妹的去抑制体征相似，但对照组明显较少，表明其具有家族性。兄弟姐妹和对照组的锥体外系及感觉整合体征相似，但患者明显更严重，提示为非家族性异常。总之，这些发现可能意味着不同亚组的神经学体征有不同的病因学起源。
