Providence VA Medical Center, Harvard Medical School, Cambridge, Massachusetts, United States of America.
PLoS One. 2013 Apr 4;8(4):e60885. doi: 10.1371/journal.pone.0060885. Print 2013.
Increased neurological soft signs (NSSs) have been found in a number of neuropsychiatric syndromes, including chemical addiction. The present study examined NSSs related to perceptual-motor and visuospatial processing in a behavioral addiction viz., pathological gambling (PG). As compared to mentally healthy individuals, pathological gamblers displayed significantly poorer ability to copy two- and three-dimensional figures, to recognize objects against a background noise, and to orient in space on a road-map test. Results indicated that PG is associated with subtle cerebral cortical abnormalities. Further prospective clinical research is needed to address the NSSs' origin and chronology (e.g., predate or follow the development of PG) as well as their response to therapeutic interventions and/or their ability to predict such a response.
在许多神经精神综合征中，包括化学成瘾，都发现了神经学软体征（NSSs）的增加。本研究在一种行为成瘾即病理性赌博（PG）中检查了与知觉运动和视空间加工相关的 NSSs。与心理健康个体相比，病理性赌徒在复制二维和三维图形、识别背景噪音中的物体以及在路线图测试中进行空间定向的能力明显较差。结果表明，PG 与微妙的大脑皮层异常有关。需要进一步的前瞻性临床研究来解决 NSSs 的起源和时间顺序（例如，早于或晚于 PG 的发展），以及它们对治疗干预的反应和/或它们预测这种反应的能力。
