Kayl A E, Moore B D, Slopis J M, Jackson E F, Leeds N E
University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
J Child Neurol. 2000 Feb;15(2):90-6. doi: 10.1177/088307380001500206.
Neurofibromatosis-1 is a common autosomal-dominant genetic disorder associated with numerous physical anomalies and an increased incidence of attention-deficit hyperactivity disorder (ADHD). Studies of children with idiopathic ADHD have suggested a link between corpus callosum size and symptom severity. This study examines the contribution of corpus callosum morphology to symptoms of ADHD in children with neurofibromatosis. Eighteen control subjects and 36 children with neurofibromatosis underwent magnetic resonance imaging of the brain. Twelve subjects with neurofibromatosis had evidence of ADHD and 24 did not. Subjects with neurofibromatosis had significantly larger total corpus callosum area and significantly larger regional measurements in three of seven areas. However, there were no differences between the neurofibromatosis alone and neurofibromatosis plus ADHD groups. Increased severity of attention problems was associated with smaller total callosal areas. These results suggest that some features of ADHD in children with neurofibromatosis could be linked to quantifiable differences in brain morphology, but the nature of the genetic mutation in neurofibromatosis suggests that neurochemical effects also could be important.
神经纤维瘤病1型是一种常见的常染色体显性遗传病，与多种身体异常以及注意力缺陷多动障碍（ADHD）的发病率增加有关。对特发性ADHD儿童的研究表明胼胝体大小与症状严重程度之间存在联系。本研究探讨了胼胝体形态对神经纤维瘤病儿童ADHD症状的影响。18名对照受试者和36名神经纤维瘤病儿童接受了脑部磁共振成像检查。36名神经纤维瘤病受试者中，12名有ADHD证据，24名没有。神经纤维瘤病受试者的胼胝体总面积显著更大，在七个区域中的三个区域的局部测量值也显著更大。然而，单纯神经纤维瘤病组和神经纤维瘤病合并ADHD组之间没有差异。注意力问题严重程度增加与胼胝体总面积较小有关。这些结果表明，神经纤维瘤病儿童ADHD的一些特征可能与脑形态的可量化差异有关，但神经纤维瘤病基因突变的性质表明神经化学效应也可能很重要。
