Semrud-Clikeman M, Filipek P A, Biederman J, Steingard R, Kennedy D, Renshaw P, Bekken K
University of Washington, Seattle 98195.
J Am Acad Child Adolesc Psychiatry. 1994 Jul-Aug;33(6):875-81. doi: 10.1097/00004583-199407000-00014.
The following study seeks to document possible differences in corpus callosal area and shape between children with attention-deficit hyperactivity disorder (ADHD) and controls.
Fifteen carefully diagnosed right-handed male subjects with ADHD with overactivity symptomatology were compared to 15 right-handed male control subjects. The corpus callosum was divided into seven areas on the midsagittal slice of a magnetic resonance image with shape analysis also conducted.
An exploratory shape analysis showed no significant differences in shape between the groups. No group differences were found in the area, length, or anterior regions of the corpus callosum. The ADHD subjects were found to have significantly smaller posterior corpus callosum regions than the control group, with the splenium accounting for most of the variance between the groups.
The splenial area of the corpus callosum is smaller in children with ADHD than in a sample of normally developing children. These smaller areas may relate to commonly seen sustained attention deficits which in turn negatively impact on the development of more advanced levels of attention such as self-regulation. Further study of the regions surrounding the splenial area is suggested to determine whether they are correlated in size to the smaller corpus callosum.
以下研究旨在记录注意缺陷多动障碍（ADHD）儿童与对照组儿童在胼胝体区域和形状上可能存在的差异。
将15名经过仔细诊断的有多动症状的右利手男性ADHD受试者与15名右利手男性对照受试者进行比较。在磁共振图像的正中矢状切片上，将胼胝体分为七个区域，并进行形状分析。
探索性形状分析显示两组之间在形状上无显著差异。在胼胝体的面积、长度或前部区域未发现组间差异。发现ADHD受试者的胼胝体后部区域明显小于对照组，其中压部占两组间差异的大部分。
ADHD儿童的胼胝体压部面积小于正常发育儿童样本。这些较小的区域可能与常见的持续注意力缺陷有关，进而对更高级别的注意力发展（如自我调节）产生负面影响。建议进一步研究压部区域周围的区域，以确定它们的大小是否与较小的胼胝体相关。
