患有Landau-Kleffner综合征和获得性癫痫性失语症儿童的脑磁图检查
Magnetoencephalography in children with Landau-Kleffner syndrome and acquired epileptic aphasia.
作者信息
Sobel D F, Aung M, Otsubo H, Smith M C
机构信息
Division of Neuroradiology, Scripps Clinic, La Jolla, CA 92037, USA.
出版信息
AJNR Am J Neuroradiol. 2000 Feb;21(2):301-7.
BACKGROUND AND PURPOSE
Landau-Kleffner syndrome (LKS) is epileptiform aphasia acquired during childhood and occurring in children with previously normal language development. The epileptiform activity in these children is thought to result in a functional ablation of eloquent speech areas. The purpose of this study was to investigate the usefulness of magnetoencephalography (MEG) for localizing the source of epileptiform activity in these patients.
METHODS
Nineteen patients with acquired aphasia and a suspected diagnosis of LKS were referred for MEG evaluation. Patients ranged in age from 4 to 14 years. Fourteen MEG studies were performed on a 74-channel system, four on a 148-channel whole-head system, and one on a 37-channel system.
RESULTS
Thirteen of the 19 patients had perisylvian MEG spikes. In 10 of the patients, the spikes were bilateral, and in three they were unilateral. Four other patients had non-sylvian spikes, and two patients had no spikes recorded. The results of MR imaging were normal or noncontributory for all 19 patients.
CONCLUSIONS
MEG can play a useful role in evaluating children with LKS and acquired epileptiform aphasia, both in diagnosis and in aiding presurgical localization of epileptiform activity when surgery is being considered.
背景与目的
Landau-Kleffner综合征（LKS）是一种在儿童期获得性的癫痫样失语症，发生于先前语言发育正常的儿童。这些儿童的癫痫样活动被认为导致了明确的语言区域的功能性消融。本研究的目的是探讨脑磁图（MEG）在定位这些患者癫痫样活动来源方面的作用。
方法
19例获得性失语且疑似诊断为LKS的患者被转诊进行MEG评估。患者年龄在4至14岁之间。14项MEG研究在74通道系统上进行，4项在148通道全脑系统上进行，1项在37通道系统上进行。
结果
19例患者中有13例在外侧裂周围有MEG棘波。其中10例患者的棘波为双侧性，3例为单侧性。另外4例患者有非外侧裂棘波，2例患者未记录到棘波。所有19例患者的磁共振成像结果均正常或无诊断价值。
结论
MEG在评估LKS和获得性癫痫样失语症儿童方面可发挥有用作用，无论是在诊断方面，还是在考虑手术时辅助癫痫样活动的术前定位方面。
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