Mirsadykov D A, Artarian A A, Promyslov M Sh, Aref'eva I A
Zh Vopr Neirokhir Im N N Burdenko. 1999 Oct-Dec(4):26-8.
Spinal fluid radical formation levels, malonic dialdehyde concentrations, and intrinsic antioxidative activity were studied in 84 patients with hydrocephalus. The findings suggest that there is a considerable activation of free radical reactions and lipid peroxidation, as well as a reduction in antioxidative activity. These changes were most drastically profound in children with inflammation-complicated hydrocephalus with spinal fluid hemorrhagic changes in particular. Timely correction of impaired energy exchange in children by using antioxidants and nootropics promotes the arrest of inflammation and prevents a number of postoperative complications.
对84例脑积水患者的脑脊液自由基生成水平、丙二醛浓度和内源性抗氧化活性进行了研究。研究结果表明，自由基反应和脂质过氧化反应有相当程度的激活，同时抗氧化活性降低。这些变化在伴有炎症并发症尤其是脑脊液出血性改变的脑积水患儿中最为显著。通过使用抗氧化剂和促智药及时纠正患儿受损的能量代谢，可促进炎症的停止并预防一系列术后并发症。
