Aref'eva I A, Demchuk M L, Artarian A A, Mirsadykov D A, Promyslov M Sh
Burdenko Neurosurgery Institute, Moscow, Russia.
Vopr Med Khim. 1998 Jul-Aug;44(4):388-92.
The levels of free radical production, malondialdehyde concentration and antioxidant activity were estimated in ventricular liquor of the infants with primary hydrocephalus. It was shown that even in the case of uncomplicated hydrocephalus significant disorders in brain metabolism took place. In the patients with inflammatory or hemorrhagic complications the levels of malondialdehyde and free radicals were markedly increased as compared to the infants with "pure" hydrocephalus. The most significant disorders were revealed in the case of hemorrhagic complications. These data indicate the necessity of lipid peroxidation evaluation in liquor of the patients with hydrocephalus and help to workout indications for antioxidants including into the common therapy of this decrease.
对原发性脑积水婴儿的脑室液中自由基产生水平、丙二醛浓度和抗氧化活性进行了评估。结果表明，即使在单纯性脑积水的情况下，脑代谢也发生了明显紊乱。与“单纯”脑积水婴儿相比，伴有炎症或出血并发症的患者丙二醛和自由基水平显著升高。出血并发症患者的紊乱最为明显。这些数据表明有必要对脑积水患者的脑脊液进行脂质过氧化评估，并有助于制定将抗氧化剂纳入这种疾病常规治疗的指征。
