叶酸的聚谷氨酸形式：在哺乳动物细胞中的天然存在及作为底物的作用。 - Suppr | 超能文献

Polyglutamate forms of folate: natural occurrence and role as substrates in mammalian cells.

作者信息

Bertino J R, Coward J K, Cashmore A, Chello P, Panichajakul S, Horvath C G, Stout R W

出版信息

Biochem Soc Trans. 1976;4(5):853-6. doi: 10.1042/bst0040853.

DOI:10.1042/bst0040853

Abstract

摘要

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Polyglutamate forms of folate: natural occurrence and role as substrates in mammalian cells.叶酸的聚谷氨酸形式：在哺乳动物细胞中的天然存在及作为底物的作用。

Biochem Soc Trans. 1976;4(5):853-6. doi: 10.1042/bst0040853.

2

7,8-Dihydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources.7,8-二氢蝶酰寡聚-γ-L-谷氨酸：来自哺乳动物来源的纯化二氢叶酸还原酶的合成及动力学研究

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Comparative effects of folate antagonists versus enzymatic folate depletion on folate and thymidine enzymes in cultured mammalian cells.叶酸拮抗剂与酶促性叶酸耗竭对培养哺乳动物细胞中叶酸和胸苷酶的比较作用

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Thymidylate synthase, dihydrofolate reductase, folyl binder, 10-formyl-H4PteGlu synthetase, 5,10-methenyl-H4PteGlu cyclohydrolase and 5,10-methylene-H4PteGlu dehydrogenase derived from cells of human origin.胸苷酸合成酶、二氢叶酸还原酶、叶酸结合蛋白、10-甲酰四氢叶酸合成酶、5,10-亚甲基四氢叶酸环化水解酶和5,10-亚甲基四氢叶酸脱氢酶，来源于人类细胞。

Adv Exp Med Biol. 1983;163:85-94. doi: 10.1007/978-1-4757-5241-0_8.

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Accumulation of 5-methyltetrahydrofolate in cobalamin-deficient L1210 mouse leukemia cells.5-甲基四氢叶酸在钴胺素缺乏的L1210小鼠白血病细胞中的积累。

J Biol Chem. 1982 Mar 10;257(5):2144-6.

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Polyglutamylation as a factor in the trapping of 5-methyltetrahydrofolate by cobalamin-deficient L1210 cells.多聚谷氨酸化作为钴胺素缺乏的L1210细胞捕获5-甲基四氢叶酸的一个因素。

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The effect of vitamin B12 inhibition in vivo: impaired folate polyglutamate biosynthesis indicating that 5-methyltetrahydropteroylglutamate is not its usual substrate.维生素B12体内抑制作用的效果：叶酸多聚谷氨酸生物合成受损，表明5-甲基四氢蝶酰谷氨酸并非其通常的底物。

Biochem Biophys Res Commun. 1978 May 30;82(2):540-6. doi: 10.1016/0006-291x(78)90908-7.

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Effects of nitrous oxide and methotrexate administration on hepatic methionine synthetase and dihydrofolate reductase activities, hepatic folates, and formate oxidation in rats.一氧化二氮和甲氨蝶呤给药对大鼠肝脏蛋氨酸合成酶和二氢叶酸还原酶活性、肝脏叶酸以及甲酸氧化的影响。

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Analogues of folate antagonists as affinity and fluorescent probes of dihydrofolate reductase structure and function.叶酸拮抗剂类似物作为二氢叶酸还原酶结构和功能的亲和及荧光探针

Biochem Soc Trans. 1986 Apr;14(2):371-3. doi: 10.1042/bst0140371.

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Lack of intracellular conversion of dihydrohomofolate to tetrahydrohomofolate in leukemia cells with high levels of dihydrofolate reductase.在二氢叶酸还原酶水平高的白血病细胞中，二氢高叶酸缺乏向四氢高叶酸的细胞内转化。

Mol Pharmacol. 1972 May;8(3):353-61.

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Partial purification and characterization of a folate-binding protein from human choroid plexus.人脉络丛中叶酸结合蛋白的部分纯化及特性分析

Neurochem Res. 1981 Mar;6(3):333-41. doi: 10.1007/BF00964048.