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7,8-Dihydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources.

作者信息

Coward J K, Parameswaran K N, Cashmore A R, Bertino J R

出版信息

Biochemistry. 1974 Sep 10;13(19):3899-903. doi: 10.1021/bi00716a013.

DOI:10.1021/bi00716a013
PMID:4528865
Abstract
摘要

相似文献

1
7,8-Dihydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources.7,8-二氢蝶酰寡聚-γ-L-谷氨酸：来自哺乳动物来源的纯化二氢叶酸还原酶的合成及动力学研究
Biochemistry. 1974 Sep 10;13(19):3899-903. doi: 10.1021/bi00716a013.
2
Polyglutamate forms of folate: natural occurrence and role as substrates in mammalian cells.叶酸的聚谷氨酸形式：在哺乳动物细胞中的天然存在及作为底物的作用。
Biochem Soc Trans. 1976;4(5):853-6. doi: 10.1042/bst0040853.
3
Cytochemical demonstration of dihydrofolate reductase in leukaemia and other haematological diseases.白血病及其他血液系统疾病中二氢叶酸还原酶的细胞化学显示
Scand J Haematol. 1977 Jul;19(1):5-13. doi: 10.1111/j.1600-0609.1977.tb02712.x.
4
Lack of intracellular conversion of dihydrohomofolate to tetrahydrohomofolate in leukemia cells with high levels of dihydrofolate reductase.在二氢叶酸还原酶水平高的白血病细胞中，二氢高叶酸缺乏向四氢高叶酸的细胞内转化。
Mol Pharmacol. 1972 May;8(3):353-61.
5
Analogues of folate antagonists as affinity and fluorescent probes of dihydrofolate reductase structure and function.叶酸拮抗剂类似物作为二氢叶酸还原酶结构和功能的亲和及荧光探针
Biochem Soc Trans. 1986 Apr;14(2):371-3. doi: 10.1042/bst0140371.
6
Rate and extent of interconversion of tetrahydrofolate cofactors to dihydrofolate after cessation of dihydrofolate reductase activity in stationary versus log phase L1210 leukemia cells.在静止期与对数期L1210白血病细胞中，二氢叶酸还原酶活性停止后，四氢叶酸辅因子向二氢叶酸相互转化的速率和程度。
J Biol Chem. 1991 Mar 25;266(9):5445-9.
7
Immunologic heterogeneity of dihydrofolate reductase from methotrexate sensitive and resistant L1210 leukemia cells.来自甲氨蝶呤敏感和耐药L1210白血病细胞的二氢叶酸还原酶的免疫异质性。
Proc Soc Exp Biol Med. 1985 Oct;180(1):98-102. doi: 10.3181/00379727-180-42149.
8
Polyglutamyl and polylysyl derivatives of the lysine analogues of folic acid and homofolic acid.叶酸和高叶酸的赖氨酸类似物的聚谷氨酰基和聚赖氨酰基衍生物。
J Med Chem. 1976 Nov;19(11):1295-9. doi: 10.1021/jm00233a008.
9
A comparison of dihydrofolate reductase activity in intact leukemia cells and squamous cell carcinoma.完整白血病细胞与鳞状细胞癌中二氢叶酸还原酶活性的比较。
Anticancer Drug Des. 1989 Jun;4(1):79-87.
10
Rescue effect of exogenous reduced folates on methotrexate polyglutamylation and dihydrofolate reductase activity in L1210 cells.外源性还原型叶酸对L1210细胞中氨甲蝶呤多聚谷氨酸化及二氢叶酸还原酶活性的挽救作用。
Acta Biochim Pol. 1988;35(3):199-205.

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The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake.人肝脏中二氢叶酸还原酶极其缓慢且多变的活性及其对高叶酸摄入量的影响。
Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15424-9. doi: 10.1073/pnas.0902072106. Epub 2009 Aug 24.
2
Prodrug forms of N-[(4-deoxy-4-amino-10-methyl)pteroyl]glutamate-gamma-[psiP(O)(OH)]-glutarate, a potent inhibitor of folylpoly-gamma-glutamate synthetase: synthesis and hydrolytic stability.N-[(4-脱氧-4-氨基-10-甲基)蝶酰]谷氨酸-γ-[ψP(O)(OH)]-戊二酸的前药形式，一种有效的叶酰聚-γ-谷氨酸合成酶抑制剂：合成与水解稳定性
J Med Chem. 2006 Jan 26;49(2):770-88. doi: 10.1021/jm050871p.
3
Synthesis of (6R)- and (6S)-5,10-dideazatetrahydrofolate oligo-gamma-glutamates: kinetics of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase.
（6R）-和（6S）-5,10-二脱氮四氢叶酸寡聚γ-谷氨酸的合成：叶酰聚γ-谷氨酸合成酶催化的多个谷氨酸连接动力学
Org Biomol Chem. 2005 Sep 21;3(18):3388-98. doi: 10.1039/b505907k. Epub 2005 Aug 15.
4
Exploring the folate pathway in Plasmodium falciparum.探索恶性疟原虫中的叶酸途径。
Acta Trop. 2005 Jun;94(3):191-206. doi: 10.1016/j.actatropica.2005.04.002. Epub 2005 Apr 18.
5
Pharmacokinetics of erythrocyte methotrexate after high-dose methotrexate.
Cancer Chemother Pharmacol. 1982;9(1):65-9. doi: 10.1007/BF00296766.
6
Enzymatic synthesis and function of folylpolyglutamates.叶酰聚谷氨酸的酶促合成与功能
Mol Cell Biochem. 1981 Aug 11;38 Spec No(Pt 1):19-48. doi: 10.1007/BF00235686.
7
Pharmacokinetics of methotrexate in erythrocytes in psoriasis.甲氨蝶呤在银屑病患者红细胞中的药代动力学
Eur J Clin Pharmacol. 1984;27(5):607-10. doi: 10.1007/BF00556900.
8
Pteroylpolyglutamates.蝶酰多聚谷氨酸盐
Mol Cell Biochem. 1981 Sep 25;39:331-45. doi: 10.1007/BF00232583.
9
Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells.细菌和哺乳动物细胞合成叶酰多聚-γ-谷氨酸
Mol Cell Biochem. 1981 Sep 25;39:209-28. doi: 10.1007/BF00232575.
10
5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.5-氟尿嘧啶-甲氨蝶呤协同作用：二氢蝶酰多聚谷氨酸增强5-氟脱氧尿苷酸与胸苷酸合成酶的结合
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5663-7. doi: 10.1073/pnas.77.10.5663.