Karlander L E, Gustavsson U, Lidman D, Sjöberg F
Department of Plastic Surgery, Hand Surgery, and Burns, University Hospital, Linköping, Sweden.
J Trauma. 2000 Feb;48(2):286-91. doi: 10.1097/00005373-200002000-00015.
Severe contusion of an artery often presents clinical problems in that it affects flow distal to the injury. However, the effect of a contusion on the microvascular flow regulation in the distal part of the limb is still largely unknown.
A multipoint microelectrode technique was used to assess both tissue oxygenation (PtO2) and microflow (hydrogen clearance) on the skeletal muscle surface in a standard contusion injury to the femoral vessels in rats.
A significant increase in and an altered distribution of (PtO2) as well as a reduction in and altered distribution of microflow on the muscle surface distal to the injury was found in all animals (n = 27) compared with the uninjured control leg. These findings could not be reproduced experimentally by sympathectomy or when the adjacent skeletal muscle alone was injured.
The results suggest that the changes observed distal to the injury are of vascular origin, possibly as a result of endothelial damage at the site of the contusion.
动脉严重挫伤常引发临床问题，因为它会影响损伤部位远端的血流。然而，挫伤对肢体远端微血管血流调节的影响在很大程度上仍不清楚。
采用多点微电极技术，对大鼠股血管标准挫伤损伤处骨骼肌表面的组织氧合（PtO2）和微血流（氢清除率）进行评估。
与未受伤的对照腿相比，所有动物（n = 27）受伤部位远端肌肉表面的（PtO2）显著增加且分布改变，微血流减少且分布改变。这些发现无法通过交感神经切除术或仅相邻骨骼肌受伤时在实验中重现。
结果表明，损伤部位远端观察到的变化源于血管，可能是挫伤部位内皮损伤的结果。
