Booth S L, Mayer J
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Nutr Rev. 2000 Jan;58(1):20-2. doi: 10.1111/j.1753-4887.2000.tb01820.x.
Two recent studies examined the association between chronic use of warfarin, a vitamin K antagonist, and fracture rate among older women. Whereas one study reported no association, the other reported a significantly higher risk for vertebral and rib fractures among warfarin users compared with nonusers. The effect of vitamin K antagonists on age-related bone loss continues to be controversial.
最近的两项研究探讨了长期使用维生素K拮抗剂华法林与老年女性骨折率之间的关联。一项研究报告称二者无关联，而另一项研究则报告称，与未使用者相比，华法林使用者发生脊椎和肋骨骨折的风险显著更高。维生素K拮抗剂对与年龄相关的骨质流失的影响仍存在争议。
