Jenkins T D, Friedman L S
Gastroenterology Division, Hospital of the University of Pennsylvania, Philadelphia, USA.
Dig Dis. 1999;17(3):153-62. doi: 10.1159/000016920.
Adenocarcinoma of the esophagogastric junction (EGJ) has increased rapidly in incidence in the latter half of the twentieth century. The increase in incidence has affected white men between the ages of 40 and 60 disproportionately. Understanding the etiology and improving treatment requires careful classification of EGJ tumors. A recent consensus conference recognized three types of EGJ adenocarcinomas: distal esophageal, cardia, and subcardia gastric. Distal esophageal adenocarcinomas are associated with Barrett's esophagus. Helicobacter pylori infection may play a role in some adenocarcinomas of the subcardia, but the association is unproven. Therapy for all types of EGJ tumors is surgical, but multimodal forms of treatment are commonly used because of the advanced stage at which these tumors often present. Several endoscopic options exist for primary therapy of early-stage tumors and for palliation.
食管胃交界（EGJ）腺癌的发病率在20世纪后半叶迅速上升。发病率的增加对40至60岁的白人男性影响尤为严重。了解病因并改善治疗需要对EGJ肿瘤进行仔细分类。最近的一次共识会议确认了三种类型的EGJ腺癌：食管远端型、贲门型和贲门下胃型。食管远端腺癌与巴雷特食管相关。幽门螺杆菌感染可能在一些贲门下腺癌中起作用，但这种关联尚未得到证实。所有类型的EGJ肿瘤的治疗方法都是手术，但由于这些肿瘤通常在晚期出现，多模式治疗方法也常用。对于早期肿瘤的初始治疗和缓解症状，有几种内镜治疗选择。
