Marsman W A, Tytgat G N J, ten Kate F J W, van Lanschot J J B
Departments of Surgery and Gastroenterology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
J Surg Oncol. 2005 Dec 1;92(3):160-8. doi: 10.1002/jso.20358.
During the last few decades there has been an alarming rise in the incidence of tumors originating at the esophagogastric junction (EGJ) [1]. The reason for this is unknown. Tumors of the EGJ can be categorized in two types of cancer divided according to their anatomical origin: distal esophageal adenocarcinoma and adenocarcinoma of the gastric cardia. However, due to their location, in the transitional zone of the esophagus and stomach, there is constant debate about the proper classification, staging, and management of these tumors. The etiology of distal esophageal adenocarcinoma is clearly related to gastroesophageal reflux disease (GERD) and the development of a Barrett's esophagus [2]. The etiology of adenocarcinoma of the gastric cardia is less well understood. In the present paper, we will discuss the clinical characteristics and clinical management of esophagogastric tumors. Special attention will be given to differences and similarities of adenocarcinomas of the gastric cardia and distal esophagus.
在过去几十年间，食管胃交界（EGJ）处原发肿瘤的发病率呈惊人的上升趋势[1]。其原因尚不明。EGJ处的肿瘤可根据解剖学起源分为两种类型的癌症：食管远端腺癌和贲门腺癌。然而，由于它们位于食管和胃的过渡区域，关于这些肿瘤的正确分类、分期及管理一直存在争议。食管远端腺癌的病因显然与胃食管反流病（GERD）及巴雷特食管的形成有关[2]。贲门腺癌的病因则了解较少。在本文中，我们将讨论食管胃肿瘤的临床特征及临床管理。将特别关注贲门腺癌和食管远端腺癌的异同。
