Mattson S N, Riley E P
Center for Behavioral Teratology, San Diego State University, California, USA.
Alcohol Clin Exp Res. 2000 Feb;24(2):226-31.
Behavioral disturbances are well documented in children with heavy prenatal alcohol exposure. However, the degree to which these disturbances are related to factors other than alcohol, such as general intellectual functioning or socioeconomic status, is not known.
Using the Child Behavior Checklist, parent-rated behaviors of children with histories of heavy prenatal alcohol exposure were compared with those of a control group matched by age, sex, socioeconomic status, ethnicity, and verbal IQ score. Using this same questionnaire, children with fetal alcohol syndrome were compared with children with heavy prenatal alcohol exposure that did not meet the criteria for fetal alcohol syndrome classification.
Data were analyzed by multivariate analyses of covariance. In the comparison of children with and without a history of prenatal alcohol exposure, significant differences were found on the competence, problem, and summary scales (all p < 0.05). For the secondary comparison between the fetal alcohol syndrome and the heavy prenatal alcohol exposure groups, there were no significant differences on any of the scales (allp > 0.10).
These results suggest that prenatal alcohol exposure results in the significant and profound impairment of parent-rated behaviors and that these deficits are not explained entirely by the presence or absence of facial dysmorphology, general intellectual functioning, or demographic factors.
产前大量接触酒精的儿童存在行为障碍,这已得到充分证实。然而,这些障碍与酒精以外的因素(如一般智力功能或社会经济地位)的关联程度尚不清楚。
使用儿童行为量表,将有产前大量接触酒精史的儿童的家长评定行为与按年龄、性别、社会经济地位、种族和语言智商得分匹配的对照组儿童的行为进行比较。使用相同问卷,将胎儿酒精综合征患儿与未达到胎儿酒精综合征分类标准的产前大量接触酒精的儿童进行比较。
通过多变量协方差分析对数据进行分析。在有和没有产前酒精接触史的儿童比较中,在能力、问题和总结量表上发现了显著差异(所有p<0.05)。在胎儿酒精综合征组和产前大量接触酒精组的二次比较中,任何量表上均无显著差异(所有p>0.10)。
这些结果表明,产前酒精接触会导致家长评定行为出现显著且严重的损害,而且这些缺陷不能完全由面部畸形、一般智力功能或人口统计学因素的有无来解释。