Schneier F R, Liebowitz M R, Abi-Dargham A, Zea-Ponce Y, Lin S H, Laruelle M
Anxiety Disorders Clinic and the Brain Imaging Division, New York State Psychiatric Institute, New York 10032, USA.
Am J Psychiatry. 2000 Mar;157(3):457-9. doi: 10.1176/appi.ajp.157.3.457.
This study compared dopamine D(2) receptor binding potential in patients with social phobia and healthy comparison subjects.
Dopamine D(2) receptor binding potential was assessed in 10 unmedicated subjects with generalized social phobia and no significant lifetime psychiatric comorbidity and 10 healthy comparison subjects matched for age and sex. Binding potential was measured in the striatum by using single photon emission computerized tomography and constant infusion of the D(2) receptor radiotracer [(123)I]iodobenzamide ([(123)I]IBZM).
Mean D(2) receptor binding potential was significantly lower in the subjects with social phobia than in the comparison subjects. Within the social phobia group, there was a nonsignificant correlation of binding potential with the Liebowitz Social Anxiety Scale score.
Generalized social phobia may be associated with low binding of [(123)I]IBZM to D(2) receptors in the striatum.
本研究比较社交恐惧症患者与健康对照者的多巴胺D(2)受体结合潜能。
对10名未接受药物治疗、患有广泛性社交恐惧症且无显著终生精神疾病共病的受试者以及10名年龄和性别匹配的健康对照者进行多巴胺D(2)受体结合潜能评估。通过单光子发射计算机断层扫描和持续注入D(2)受体放射性示踪剂[(123)I]碘苄酰胺([(123)I]IBZM)来测量纹状体中的结合潜能。
社交恐惧症受试者的平均D(2)受体结合潜能显著低于对照受试者。在社交恐惧症组内，结合潜能与利伯维茨社交焦虑量表评分之间存在不显著的相关性。
广泛性社交恐惧症可能与[(123)I]IBZM在纹状体中与D(2)受体的低结合有关。
