Schneier Franklin R, Martinez Diana, Abi-Dargham Anissa, Zea-Ponce Yolanda, Simpson H Blair, Liebowitz Michael R, Laruelle Marc
Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, NY 10032, USA.
Depress Anxiety. 2008;25(1):1-7. doi: 10.1002/da.20268.
Dopamine D(2) receptor availability in the striatum has been reported to be low in generalized social anxiety disorder (GSAD) and obsessive-compulsive disorder (OCD), but it has not been studied in persons with comorbid OCD and GSAD (OCD+GSAD). D(2) receptor availability was assessed in 7 subjects with OCD+GSAD, 8 with OCD, and 7 matched healthy comparison (HC) subjects, all unmedicated adults. D(2) receptor availability was assessed with single-photon emission computerized tomography (SPECT) to measure binding potential (BP) of the D(2) receptor radiotracer [(123)I] iodobenzamide ([(123)I]IBZM). Mean striatal [(123)I]IBZM BP was significantly lower in the OCD+GSAD group (72.58 mL/g, SD=18.17) than in the HC group (118.41 mL/g, SD=45.40; P=.025). Mean BP in the OCD group (93.08 mL/g, SD=36.90) did not differ significantly from the HC group (P=.247). Trait detachment, as measured by the Detachment subscale of the Karolinska Scales of Personality, was negatively correlated with D(2) availability across all subjects (r(s)= -.55, P=.013). Comorbid GSAD and OCD may be associated with decreased availability of D(2) receptors in the striatum, consistent with prior findings in GSAD. Prior findings of decreased D(2) receptor availability in noncomorbid OCD were not confirmed. Decreased D(2) receptor availability was also associated with trait detachment, supporting prior findings in samples of healthy subjects.
据报道，在广泛性社交焦虑障碍（GSAD）和强迫症（OCD）患者中，纹状体中的多巴胺D(2)受体可用性较低，但尚未对共病OCD和GSAD（OCD+GSAD）的患者进行研究。对7名患有OCD+GSAD的受试者、8名患有OCD的受试者和7名匹配的健康对照（HC）受试者（均为未接受药物治疗的成年人）的D(2)受体可用性进行了评估。使用单光子发射计算机断层扫描（SPECT）评估D(2)受体可用性，以测量D(2)受体放射性示踪剂[(123)I]碘苯甲酰胺（[(123)I]IBZM）的结合潜能（BP）。OCD+GSAD组的平均纹状体[(123)I]IBZM BP（72.58 mL/g，标准差=18.17）显著低于HC组（118.41 mL/g，标准差=45.40；P=0.025）。OCD组的平均BP（93.08 mL/g，标准差=36.90）与HC组无显著差异（P=0.247）。通过卡罗林斯卡人格量表的分离分量表测量的特质分离与所有受试者的D(2)可用性呈负相关（斯皮尔曼相关系数r(s)= -0.55，P=0.013）。GSAD和OCD共病可能与纹状体中D(2)受体可用性降低有关，这与GSAD的先前研究结果一致。非共病OCD中D(2)受体可用性降低的先前研究结果未得到证实。D(2)受体可用性降低也与特质分离有关，支持了健康受试者样本中的先前研究结果。
