Alany R G, Rades T, Agatonovic-Kustrin S, Davies N M, Tucker I G
School of Pharmacy, University of Otago, Dunedin, New Zealand.
Int J Pharm. 2000 Mar 10;196(2):141-5. doi: 10.1016/s0378-5173(99)00408-1.
The aim of the current study was to investigate the effect of different co-surfactants on the phase behaviour of the pseudoternary system water:ethyl oleate:nonionic surfactant blend (sorbitan monolaurate/polyoxyethylene 20 sorbitan mono-oleate). Four aliphatic alcohols (1-propanol, 1-butanol, 1-hexanol and 1-octanol) and four 1, 2-alkanediols (1,2-propanediol, 1,2-pentanediol, 1,2-hexanediol and 1,2-octanediol) were used. The co-surfactant-free system forms two different colloidal structures, a water-in-oil microemulsion (w/o ME) and lamellar liquid crystals (LC) and two coarse dispersions, water-in-oil (w/o EM) and oil-in-water (o/w EM) emulsions. Microemulsion region area (%ME), liquid crystalline region area (%LC), amount of amphiphile blend required to produce a balanced microemulsion (%AMPH) and amount of water solubilised (%W) were used as assessment criteria to evaluate the co-surfactants. Seven calculated physico-chemical descriptors were used to represent the different co-surfactants. 1-butanol, 1,2-hexanediol and 1, 2-octanediol produced balanced MEs capable of solubilising a high percentage of both oil and water. A similarity was observed between the descriptors attributed to 1-butanol and 1,2-hexanediol. The requirements of a co-surfactant molecule to produce a balanced microemulsion were: HLB value 7.0-8.0, a carbon backbone of 4-6 atoms, percentage carbon of 60-65%, percentage oxygen of 20-30%, logP value 0.2-0.9 and log 1/S (S: aqueous solubility) close to zero.
油酸乙酯：非离子表面活性剂混合物（山梨醇单月桂酸酯/聚氧乙烯20山梨醇单油酸酯）相行为的影响。使用了四种脂肪醇（1-丙醇、1-丁醇、1-己醇和1-辛醇）和四种1,2-链烷二醇（1,2-丙二醇、1,2-戊二醇、1,2-己二醇和1,2-辛二醇）。无助表面活性剂体系形成两种不同的胶体结构，油包水微乳液（w/o ME）和层状液晶（LC）以及两种粗分散体，油包水（w/o EM）和水包油（o/w EM）乳液。微乳液区域面积（%ME）、液晶区域面积（%LC）、产生平衡微乳液所需的两亲混合物量（%AMPH）和增溶水量（%W）用作评估助表面活性剂的标准。使用七个计算得到的物理化学描述符来表征不同的助表面活性剂。1-丁醇、1,2-己二醇和1,2-辛二醇产生了能够增溶高比例油和水的平衡微乳液。观察到归因于1-丁醇和1,2-己二醇的描述符之间存在相似性。助表面活性剂分子产生平衡微乳液的要求为：HLB值7.0 - 8.0、4 - 6个原子的碳主链、60 - 65%的碳百分比、20 - 30%的氧百分比、logP值0.2 - 0.9以及log 1/S（S：水溶性）接近零。
