Sgambato A, Cittadini A, Faraglia B, Weinstein I B
Centro di Ricerche Oncologiche "Giovanni XXIII," Catholic University, Rome, Italy.
J Cell Physiol. 2000 Apr;183(1):18-27. doi: 10.1002/(SICI)1097-4652(200004)183:1<18::AID-JCP3>3.0.CO;2-S.
Cyclin-dependent kinases (CDKs), together with cyclins, their regulatory subunits, govern cell-cycle progression in eukaryotic cells. p27(Kip1) is a member of a family of CDK inhibitors (CDIs) that bind to cyclin/CDK complexes and arrest cell division. There is considerable evidence that p27(Kip1) plays an important role in multiple fundamental cellular processes, including cell proliferation, cell differentiation, and apoptosis. Moreover, p27(Kip1) is a putative tumor-suppressor gene that appears to play a critical role in the pathogenesis of several human malignancies and its reduced expression has been shown to correlate with poor prognosis in cancer patients. This study reviews current information on the functions of p27(Kip1), its abnormalities found in human tumors, and the possible clinical implications of these findings with respect to the management of cancer patients.
细胞周期蛋白依赖性激酶（CDK）与细胞周期蛋白及其调节亚基共同调控真核细胞的细胞周期进程。p27（Kip1）是细胞周期蛋白依赖性激酶抑制剂（CDI）家族的一员，它与细胞周期蛋白/细胞周期蛋白依赖性激酶复合物结合并阻止细胞分裂。有大量证据表明，p27（Kip1）在包括细胞增殖、细胞分化和细胞凋亡在内的多个基本细胞过程中发挥重要作用。此外，p27（Kip1）是一种假定的肿瘤抑制基因，似乎在几种人类恶性肿瘤的发病机制中起关键作用，其表达降低已被证明与癌症患者的不良预后相关。本研究综述了关于p27（Kip1）功能的当前信息、在人类肿瘤中发现的其异常情况以及这些发现对癌症患者管理可能的临床意义。
