Barbareschi M
Department of Pathology, S. Chiara Hospital, Trento, Italy.
Adv Clin Path. 1999 Oct;3(4):119-27.
p27 KIP1 is a cyclin dependent kinase inhibitor, which may act as a potential suppressor gene. Several lines of evidence support the hypothesis that reduced p27 KIP1 expression is related to uncontrolled cell proliferation and tumorigenesis. Low immunohistochemical expression of p27 KIP1 in human neoplasm seems related to tumor progression and poor prognosis. In breast cancer, low p27 is associated with high tumour grade and loss of oestrogen receptor, and it has been suggested that low p27 KIP1 is a powerful and independent prognostic marker of poor clinical outcome. There are however some discrepant results: a few studies, some of which conducted on large series of patients, do not support an independent role of p27 KIP1 as a prognostic marker. We are indeed faced with an intriguing hypothesis, but many more studies are needed to evaluate the real value of p27 KIP1 as a prognostic marker.
p27 KIP1是一种细胞周期蛋白依赖性激酶抑制剂，可能作为一种潜在的抑癌基因。多项证据支持以下假说：p27 KIP1表达降低与细胞增殖失控和肿瘤发生有关。p27 KIP1在人类肿瘤中的免疫组化低表达似乎与肿瘤进展和不良预后有关。在乳腺癌中，低水平的p27与高肿瘤分级和雌激素受体缺失相关，并且有人提出低水平的p27 KIP1是临床结局不良的一个有力且独立的预后标志物。然而，也有一些不一致的结果：一些研究，其中一些是对大量患者进行的研究，并不支持p27 KIP1作为预后标志物的独立作用。我们确实面临着一个有趣的假说，但需要更多的研究来评估p27 KIP1作为预后标志物的实际价值。
