Rostom A Y, Powe J, Kandil A, Ezzat A, Bakheet S, el-Khwsky F, el-Hussainy G, Sorbris R, Sjoklint O
Department of Oncology, King Faisal Specialist Hospital & Research Center, Saudi Arabia.
Br J Radiol. 1999 Nov;72(863):1064-8. doi: 10.1259/bjr.72.863.10700822.
We conducted a retrospective study to evaluate the sensitivity, specificity and accuracy of positron emission tomography (PET) scans in 109 patients with primary recurrent or metastatic breast cancer. All patients had a PET scan, X-ray or CT scan of the chest, an ultrasound or CT scan of the liver and a bone scan. Mammography was available for 86 patients. Correlation between the PET scan result and histological findings were made. The sensitivity, specificity and accuracy of the PET scan were calculated for both the primary tumour (T) and lymph nodes (N). In patients with metastasis (M) the accuracy of the PET scan was compared with other imaging modalities. Histological results of the site in question were available in only 105 patients. Information for the primary tumour was available for 93 patients and for nodes in 74. The PET scan was accurate in 89.2% for (T), with 3.2% false positive and 7.6% false negative. For (N) the PET scan was accurate in 90.5% with 9.5% false negative. In the 86 patients who underwent both mammography and PET scanning, the PET scan was more accurate in 89.5% versus 72% (p = 0.0003). In the 19 patients with metastasis, the PET scan was in agreement with other imaging modalities in 100% of cases. PET scanning is the only non-invasive imaging procedure that will detect tumours in the breast, lymph nodes, lung, liver, bone and bone marrow with high sensitivity, specificity and accuracy. It is a valuable tool in the management of patients in all stages of breast cancer for diagnosis, staging and following treatment response.
我们进行了一项回顾性研究，以评估正电子发射断层扫描（PET）对109例原发性复发性或转移性乳腺癌患者的敏感性、特异性和准确性。所有患者均接受了PET扫描、胸部X线或CT扫描、肝脏超声或CT扫描以及骨扫描。86例患者进行了乳房X线摄影。将PET扫描结果与组织学结果进行了相关性分析。计算了PET扫描对原发性肿瘤（T）和淋巴结（N）的敏感性、特异性和准确性。对于有转移（M）的患者，将PET扫描的准确性与其他成像方式进行了比较。仅105例患者获得了相关部位的组织学结果。93例患者获得了原发性肿瘤的信息，74例患者获得了淋巴结的信息。PET扫描对（T）的准确率为89.2%，假阳性率为3.2%，假阴性率为7.6%。对于（N），PET扫描的准确率为90.5%，假阴性率为9.5%。在86例同时接受乳房X线摄影和PET扫描的患者中，PET扫描的准确率为89.5%，而乳房X线摄影为72%（p = 0.0003）。在19例有转移的患者中，PET扫描在100%的病例中与其他成像方式一致。PET扫描是唯一一种能够以高敏感性、特异性和准确性检测乳腺、淋巴结、肺、肝、骨和骨髓肿瘤的非侵入性成像检查。它是乳腺癌各阶段患者管理中用于诊断、分期和跟踪治疗反应的有价值工具。
