Azuma Asako, Tozaki Mitsuhiro, Ito Kensuke, Fukuma Eisuke, Tanaka Tomoko, O'uchi Toshihiro
Department of Radiology, Kameda Medical Center, 929 Higashi-cho, Kamogawa, 296-8602, Japan.
Radiat Med. 2008 Oct;26(8):488-93. doi: 10.1007/s11604-008-0263-6. Epub 2008 Oct 31.
The aim of this study was to determine if any correlation exists between tumor cell density and fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET)/CT) for pure or predominant ductal carcinoma in situ (DCIS).
Subjects in this retrospective review comprised 11 patients who underwent FDG-PET/CT for DCIS. Pathological tumor cell density and FDG-PET/CT images were compared. A tumor background count density ratio of >1.5 was defined as the detectable range for DCIS.
Pathological density of disease was high in eight patients, intermediate in one, and low in two. In all eight patients with a detectable intraductal component on PET/CT, the density of disease was classified as high. In three patients undetected by PET/CT, the density of disease was classified as intermediate or low. On statistical analysis, the correlation between the density of disease and tumor background count density ratio (TBCDR) on PET/CT was significant (<0.05), whereas the nuclear grade and Van Nuys grade were not significant. In the eight patients detected by PET/CT, the discrepancy between histopathological mapping and FDG-PET/CT mapping was >20 mm in four patients and represented underestimation in four patients who showed low density of disease in the peripheral area.
Tumor cell density of intraductal carcinoma appears strongly correlated to detection by FDG-PET/CT.
本研究旨在确定纯原位导管癌（DCIS）或主要为原位导管癌的肿瘤细胞密度与氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）之间是否存在相关性。
本回顾性研究的对象包括11例因DCIS接受FDG-PET/CT检查的患者。比较病理肿瘤细胞密度和FDG-PET/CT图像。肿瘤背景计数密度比>1.5被定义为DCIS的可检测范围。
8例患者疾病的病理密度高，1例中等，2例低。在PET/CT上可检测到导管内成分的所有8例患者中，疾病密度被分类为高。在PET/CT未检测到的3例患者中，疾病密度被分类为中等或低。经统计学分析，疾病密度与PET/CT上的肿瘤背景计数密度比（TBCDR）之间存在显著相关性（<0.05），而核分级和Van Nuys分级不显著。在PET/CT检测到的8例患者中，4例患者组织病理学定位与FDG-PET/CT定位之间的差异>20 mm，4例疾病外周区域密度低的患者表现为低估。
导管内癌的肿瘤细胞密度似乎与FDG-PET/CT检测密切相关。
