Ohshima H, Yamashiro K, Yamamoto M, Hirata K, Okazaki A, Ohmura T, Okazaki M, Watanabe Y
Dept. of Surgery, Akabira City Hospital.
Gan To Kagaku Ryoho. 2000 Feb;27(2):239-44.
We administered neoadjuvant chemotherapy by a selective intra-arterial infusion method using a trans-radial approach in patients with advanced breast cancer (stage III and stage IV). The trans-radial approach uses the arterial flow, based on the Seldinger technique. In this method, the radial artery is cannulated, and epirubucin is infused into the artery that carries blood from the subclavical artery to the breast. We have used this method in 4 cases thus far. Two of the patients received a single intra-arterial infusion of epirubicin. The other 2 patients were catheterized before they received chemotherapy by intra-arterial infusion. This technique decreased the pain or discomfort caused by the catheterizations during chemotherapy in all 4 cases. However, the currently available catheters are not always able to approach the artery flowing into the breast, thus the protocol will need to be refined.
我们采用经桡动脉途径的选择性动脉内灌注方法，对晚期乳腺癌（III期和IV期）患者进行新辅助化疗。经桡动脉途径基于Seldinger技术利用动脉血流。在该方法中，经皮穿刺桡动脉，将表柔比星注入从锁骨下动脉向乳房供血的动脉。到目前为止，我们已将此方法应用于4例患者。其中2例患者接受了单次动脉内表柔比星灌注。另外2例患者在接受动脉内灌注化疗前进行了插管。该技术在所有4例患者中均减轻了化疗期间插管引起的疼痛或不适。然而，目前可用的导管并不总是能够到达流入乳房的动脉，因此该方案需要进一步完善。
