Takatsuka Y, Kawahara T, Yayoi E, Okamura J, Miyauchi K, Shiba E, Mori T
Dept. of Surgery, Osaka National Hospital.
Gan To Kagaku Ryoho. 1991 Aug;18(11):1740-3.
A comparative randomized study of intra-arterial infusion chemotherapy (IA) and systemic chemotherapy (IV) was carried out on 41 patients with locally advanced breast cancer, and the following results were obtained. 1) The response rate of primary lesions to IA (63.2%) was better than that of IV (40.9%). 2) In the patients treated with IA, grade of leukopenia, as well as the percentage of gastro-intestinal disorders, was low. 3) More prolonged follow-up studies are required on the therapeutic effects on micrometastasis. The author confirmed that IA was an efficacious neoadjuvant therapy in terms of down staging of locally advanced breast cancer.
对41例局部晚期乳腺癌患者进行了动脉内灌注化疗（IA）与全身化疗（IV）的比较随机研究，结果如下：1）IA组原发灶的缓解率（63.2%）优于IV组（40.9%）。2）接受IA治疗的患者白细胞减少程度以及胃肠道疾病的发生率较低。3）关于对微转移的治疗效果，需要进行更长时间的随访研究。作者证实，就局部晚期乳腺癌的降期而言，IA是一种有效的新辅助治疗方法。
