Mobit P N, Sandison G A, Nahum A E
Department of Medical Physics, Tom Baker Cancer Center, and University of Calgary, Alberta, Canada.
Phys Med Biol. 2000 Feb;45(2):255-65. doi: 10.1088/0031-9155/45/2/301.
The perturbation correction factor gamma(p) is defined as the deviation of the absorbed dose in the medium from that predicted by the Spencer-Attix extension of the Bragg-Gray cavity theory where the medium occupies exactly the same volume as the solid state cavity and the electron fluence energy spectrum in the cavity is identical in shape, but not necessarily in magnitude, to that in the medium. The value of gamma(p) has been examined for TL detectors irradiated in megavoltage electron beams (5-20 MeV) using the EGS4 Monte Carlo code. LiF and CaF2 solid state detectors simulated were standard size discs of thickness 1 mm and diameter 3.61 mm irradiated in a water phantom with their centres at d(max) or close to it. Values of gamma(p) for LiF ranged from 0.998 +/- 0.005 to 0.994 +/- 0.005 for electron beams with initial energies of 5 and 20 MeV respectively. For CaF2 the corresponding values were 0.956 +/- 0.006 to 0.989 +/- 0.006 for the same size cavities irradiated at the same depth. EGS4 Monte Carlo simulations demonstrate that the total electron fluence (primary electrons and delta-rays) in these solid state detector materials is significantly different from that in water for the same incident electron energy and depth of irradiation. Thus the Spencer-Attix assumption that the electron fluence energy spectrum in the cavity is identical in shape to that in the medium is violated. Differences in the total electron fluence give rise to electron fluence perturbation correction factors which were up to 5% less than unity for CaF2, indicating a strong violation in this case, but were generally less than 1% for LiF. It is the density of the cavity which perturbs the electron fluence, but it is actually the atomic number differences between the medium and cavity that are responsible for the large electron fluence perturbation correction factors for detectors irradiated close to d(max) because the atomic number affects the change in stopping power with energy. When correction is made for the difference between the electron fluence spectrum in the uniform water phantom and the solid state cavity, the Spencer-Attix cavity equation predicts the dose to water within 0.3% in both clinical and monoenergetic electron beams. Harder's formulation for computing the average mass collision stopping power of water to calcium fluoride, surprisingly, requires perturbation correction factors that are closer to unity than those determined using the Spencer-Attix integrals at depths close to d(max).
微扰校正因子γ(p)的定义为:介质中的吸收剂量与布拉格-格雷空腔理论的斯宾塞-阿蒂克斯扩展所预测的吸收剂量之间的偏差,其中介质占据与固态空腔完全相同的体积,且空腔内的电子注量能谱在形状上与介质中的相同,但大小不一定相同。已使用EGS4蒙特卡罗代码对在兆伏电子束(5 - 20 MeV)中辐照的热释光探测器的γ(p)值进行了研究。模拟的LiF和CaF2固态探测器为标准尺寸的圆盘,厚度为1 mm,直径为3.61 mm,在水模体中进行辐照,其中心位于d(max)或接近d(max)处。对于初始能量分别为5 MeV和20 MeV的电子束,LiF的γ(p)值范围为0.998±0.005至0.994±0.005。对于CaF2,在相同深度对相同尺寸的空腔进行辐照时,相应的值为0.956±0.006至0.989±0.006。EGS4蒙特卡罗模拟表明,对于相同的入射电子能量和辐照深度,这些固态探测器材料中的总电子注量(初级电子和δ射线)与水中的总电子注量显著不同。因此,斯宾塞-阿蒂克斯关于空腔内电子注量能谱在形状上与介质中的相同的假设被违反。总电子注量的差异产生了电子注量微扰校正因子,对于CaF2,该校正因子比1小高达5%,表明在这种情况下有强烈的违反,但对于LiF,通常小于1%。是空腔的密度扰乱了电子注量,但实际上是介质与空腔之间的原子序数差异导致了在接近d(max)处辐照的探测器的大电子注量微扰校正因子,因为原子序数会影响阻止本领随能量的变化。当对均匀水模体和固态空腔中的电子注量谱差异进行校正后,斯宾塞-阿蒂克斯空腔方程在临床和单能电子束中均能在0.3%的误差范围内预测水的剂量。令人惊讶的是,哈德计算水对氟化钙的平均质量碰撞阻止本领的公式所需的微扰校正因子比在接近d(max)的深度处使用斯宾塞-阿蒂克斯积分确定的校正因子更接近1。