Robertson D M, Buettner H, Bennett S R
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.
Trans Am Ophthalmol Soc. 1999;97:407-27; discussion 427-34.
To report short-term follow-up of eyes containing small choroidal melanomas that were treated with transpupillary thermotherapy (TTT).
Twenty eyes with suspected small choroidal melanomas were treated with TTT using infrared light delivered from the diode laser.
The age of patients ranged from 26 to 82 years. In 14, there was documented growth of the melanoma prior to TTT. Tumor thicknesses ranged from less than 1 to 3.2 mm. Seven tumors were treated more than once. Follow-up ranged from 6 months to more than 3 years. Following treatment, tumor thicknesses decreased in all cases, usually within 2 months. Progressive atrophy of tumor mass and loss of pigmentation within the tumor continued beyond 1 year of follow-up in some eyes. Complications included field defects, vascular changes, and macular abnormalities.
Transpupillary thermotherapy of small choroidal melanomas is usually followed by early tumor shrinkage but is complicated by dense scotomas, nerve fiber bundle defects, and occasionally macular abnormalities. Short-term follow-up suggests that TTT may arrest growth of selected small melanomas.
报告接受经瞳孔温热疗法（TTT）治疗的含有小脉络膜黑色素瘤的眼睛的短期随访情况。
使用二极管激光发出的红外光，对20只疑似患有小脉络膜黑色素瘤的眼睛进行TTT治疗。
患者年龄在26至82岁之间。14例在TTT治疗前有黑色素瘤生长记录。肿瘤厚度从小于1毫米至3.2毫米不等。7个肿瘤接受了不止一次治疗。随访时间从6个月至3年以上。治疗后，所有病例的肿瘤厚度均下降，通常在2个月内。在一些眼睛中，随访超过1年后，肿瘤块持续进行性萎缩且肿瘤内色素沉着丧失。并发症包括视野缺损、血管变化和黄斑异常。
小脉络膜黑色素瘤经瞳孔温热疗法通常会使肿瘤早期缩小，但会并发浓密暗点、神经纤维束缺损，偶尔还会出现黄斑异常。短期随访表明，TTT可能会阻止某些小黑色素瘤的生长。
