Saakian S V, Val'skiĭ V V, Semenova E A, Amirian A G
Vestn Oftalmol. 2009 Nov-Dec;125(6):11-5.
Thirty-eight patients (16 males and 22 females) with recurrent and residual choroidal melanomas who had undergone brachytherapy were followed up. The indication for transpupillary thermotherapy (TTT) was an active residual tumor (36 patients) and recurrent melanoma (2 patients). The follow-up interval between brachytherapy and TTT was 10 to 127 months. TTT using a diode laser was performed on a Nidek DC 3300 device at a wavelength of 810 nm. The mean tumor prominence prior to TTT was 1.9 mm (range 1 to 3.5 mm), its mean diameter was 8.6 mm (range 4-14.5 mm). Twenty patients were observed over time. The follow-up time after TTT was 3 to 15 months. After the first session of TTT, a positive effect was observed in 15 patients. In 9 patients, the effect was inadequate, which required additional sessions of TTT. Among the early TTT complications, there were superficial petechial hemorrhages, macular edema, exudative retinal detachment above the tumor. Treatment resulted in no complications in 18 patients. Late metastases were seen in none patients. Our investigations have indicated that TTT is a highly effective treatment for recurrent and residual uveal melanomas, which provides complete tumor resorption in 29% of the patients.
对38例接受过近距离放射治疗的复发性和残留性脉络膜黑色素瘤患者（16例男性和22例女性）进行了随访。经瞳孔温热疗法（TTT）的适应证为活动性残留肿瘤（36例患者）和复发性黑色素瘤（2例患者）。近距离放射治疗与TTT之间的随访间隔为10至127个月。使用二极管激光在Nidek DC 3300设备上以810 nm波长进行TTT。TTT前肿瘤的平均突出度为1.9 mm（范围1至3.5 mm），平均直径为8.6 mm（范围4 - 14.5 mm）。对20例患者进行了长期观察。TTT后的随访时间为3至15个月。第一次TTT治疗后，15例患者观察到积极效果。9例患者效果不佳，需要额外进行TTT治疗。早期TTT并发症包括浅表点状出血、黄斑水肿、肿瘤上方的渗出性视网膜脱离。18例患者治疗后未出现并发症。无一例患者出现晚期转移。我们的研究表明，TTT是复发性和残留性葡萄膜黑色素瘤的一种高效治疗方法，29%的患者肿瘤完全吸收。
