Zarbo R J, Prasad A R, Regezi J A, Gown A M, Savera A T
Henry Ford Hospital, Detroit, MI 48202, USA.
Arch Pathol Lab Med. 2000 Mar;124(3):401-5. doi: 10.5858/2000-124-0401-SGBCAC.
To evaluate cellular composition of salivary gland adenomas using 3 monoclonal antibodies that recognize a smooth muscle phenotype confirmed to be sensitive for myoepithelial differentiation.
Immunohistochemical evaluation of 25 salivary gland basal cell and canalicular adenomas.
Archival pathology material from the files of Henry Ford Hospital, Detroit, Mich, and the University of California at San Francisco.
All basal cell adenoma variants exhibit some degree of myoepithelial cell participation with periductal, epithelioid, and spindled (stromal-like) morphologic structures. Only the canalicular adenomas, even if mixed with trabecular and solid patterns, are devoid of staining with these 3 antibodies, suggesting an adenoma composed exclusively of ductal luminal cells.
There is an overlapping histomorphologic and common cellular composition of the basal cell adenoma variants with other recognized adenomas, such as pleomorphic adenoma and myoepithelioma. Relative differentiation toward 3 cell phenotypes (ductal luminal, basal, and myoepithelial) and the character of extracellular matrix production in varying proportions by the neoplastic myoepithelial cells distinguishes the spectrum of salivary gland adenomas identified in current classification schemes.
使用3种单克隆抗体评估涎腺腺瘤的细胞组成，这些抗体可识别已证实对肌上皮分化敏感的平滑肌表型。
对25例涎腺基底细胞腺瘤和小管状腺瘤进行免疫组织化学评估。
来自密歇根州底特律市亨利·福特医院档案以及加利福尼亚大学旧金山分校的存档病理材料。
所有基底细胞腺瘤变体均表现出一定程度的肌上皮细胞参与，具有导管周围、上皮样和梭形（基质样）形态结构。只有小管状腺瘤，即使与小梁状和实性模式混合，用这3种抗体染色均为阴性，提示该腺瘤仅由导管腔面细胞组成。
基底细胞腺瘤变体与其他公认的腺瘤，如多形性腺瘤和肌上皮瘤，在组织形态学和细胞组成上存在重叠。肿瘤性肌上皮细胞相对分化为3种细胞表型（导管腔面、基底和肌上皮）以及按不同比例产生细胞外基质的特性，区分了当前分类方案中所确定的涎腺腺瘤谱。
