Wagner M S, Shoup M, Pickleman J, Yong S
Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA.
Arch Pathol Lab Med. 2000 Mar;124(3):419-22. doi: 10.5858/2000-124-0419-PMMOTC.
Primary malignant melanoma of the common bile duct is rare. To our knowledge, only 6 cases have been reported previously. The pathologic diagnosis of primary malignant melanoma in extracutaneous sites often requires the use of confirmatory immunohistochemical stains and electron microscopy studies, as well as tests to rule out other possible remote or concurrent primary sites. The presence of junctional activity adjacent to the tumor is another important requisite for the diagnosis of this entity. Nevertheless, absolute exclusion of a metastatic melanoma from an unknown occult site or regressed site is not entirely possible. We describe our observations in a case of primary malignant melanoma of the common bile duct in a 48-year-old man and discuss the criteria for diagnosis of primary melanoma.
原发性胆总管恶性黑色素瘤很罕见。据我们所知，此前仅有6例报道。皮肤外部位原发性恶性黑色素瘤的病理诊断通常需要使用确诊性免疫组织化学染色和电子显微镜检查，以及排除其他可能的远处或同时存在的原发部位的检测。肿瘤旁交界性活性的存在是诊断该实体的另一个重要必要条件。然而，要完全排除来自未知隐匿部位或消退部位的转移性黑色素瘤是不太可能的。我们描述了一名48岁男性原发性胆总管恶性黑色素瘤病例的观察结果，并讨论了原发性黑色素瘤的诊断标准。
