Vakar-López F, Abrams J
Department of Pathology, University of Texas, Houston, TX 77030, USA.
Arch Pathol Lab Med. 2000 Mar;124(3):455-9. doi: 10.5858/2000-124-0455-BSCCOI.
Basaloid squamous cell carcinoma is a recently described, distinct variant of squamous cell carcinoma that arises predominantly in the upper aerodigestive tract. Herein we report a case of basaloid squamous cell carcinoma arising in the urinary bladder. The patient was a 60-year-old woman who experienced intractable urinary tract infections following multiple corrective surgical procedures for incontinence. Biopsies of cystoscopically evident flat lesions were performed, and the patient subsequently underwent a radical cystectomy. Histologically, the lesions consisted of nests of basaloid cells with brisk mitotic activity, areas of squamous differentiation along with areas of squamous metaplasia, and squamous cell carcinoma in situ. These features are similar to those of basaloid squamous cell carcinoma described elsewhere in the body. To our knowledge, this is the first reported case of basaloid squamous cell carcinoma in the urinary bladder.
基底样鳞状细胞癌是一种最近才被描述的、独特的鳞状细胞癌变体，主要发生在上呼吸消化道。在此我们报告一例发生于膀胱的基底样鳞状细胞癌。患者为一名60岁女性，在多次针对尿失禁的矫正性外科手术后出现难治性尿路感染。对膀胱镜检查可见的扁平病变进行了活检，随后患者接受了根治性膀胱切除术。组织学上，病变由具有活跃有丝分裂活性的基底样细胞巢、鳞状分化区域以及鳞状化生区域和原位鳞状细胞癌组成。这些特征与身体其他部位描述的基底样鳞状细胞癌相似。据我们所知，这是首例报告的膀胱基底样鳞状细胞癌病例。
