从马醉木（Leucothoe grayana Max.）叶片中分离异灰毒素II。其X射线晶体学分析及对小鼠的急性毒性。

Isolation of iso-grayanotoxin II from leaves of Leucothoe grayana Max. Its X-ray crystallographic analysis and acute toxicity in mice.

作者信息

Terai T, Araho D, Osakabe K, Katai M, Narama I, Matsuura T, Katakawa J, Tetsumi T, Sato M

机构信息

Department of Applied Chemistry, Osaka Institute of Technology, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2000 Jan;48(1):142-4. doi: 10.1248/cpb.48.142.

DOI:10.1248/cpb.48.142

PMID:10705491

Abstract

The structure of iso-grayanotoxin II, a new diterpenoid from Leucothoe grayana MAX., has been determined as 3 beta,5 beta,6 beta,14 beta,16 alpha-pentahydroxygrayanotox-9(10)-ene by spectroscopic and X-ray crystallographic analysis. The lethal dosage level of iso-grayanotoxin II in mice was lower than that of grayanotoxin III.

摘要

从灰木（Leucothoe grayana MAX.）中分离得到的一种新的二萜类化合物异灰毒素II的结构，经光谱和X射线晶体学分析确定为3β,5β,6β,14β,16α-五羟基灰毒素-9(10)-烯。异灰毒素II对小鼠的致死剂量低于灰毒素III。