一名患有急性髓性白血病的儿童因头裂殖酵母引起下颌骨骨髓炎。

Mandibular osteomyelitis caused by Blastoschizomyces capitatus in a child with acute myelogenous leukemia.

作者信息

Cheung M Y, Chiu N C, Chen S H, Liu H C, Ou C T, Liang D C

机构信息

Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.

出版信息

J Formos Med Assoc. 1999 Nov;98(11):787-9.

PMID:10705698

Abstract

A 6-year-old girl with acute myelogenous leukemia (AML) developed fungal mandibular osteomyelitis during chemotherapy. Blastoschizomyces capitatus was recognized histologically by its yeast-like morphology and formation of annelloconidia, and was confirmed by culture. The fungal osteomyelitis of the mandible was treated successfully with prolonged antifungal medication, extensive surgical debridement and an oral care program, without interrupting leukemia chemotherapy. B. capitatus osteomyelitis of the mandible may occur during chemotherapy in AML patients with poor dental condition. Successful treatment can be achieved by careful management without interruption of antineoplastic chemotherapy.

摘要

一名6岁的急性髓系白血病（AML）女童在化疗期间发生了真菌性下颌骨骨髓炎。头裂殖酵母通过其酵母样形态和关节孢子的形成在组织学上得以识别，并经培养证实。通过延长抗真菌药物治疗、广泛的外科清创术和口腔护理计划，成功治疗了下颌骨真菌性骨髓炎，且未中断白血病化疗。下颌骨头裂殖酵母骨髓炎可能发生在牙齿状况不佳的AML患者化疗期间。通过精心管理且不中断抗肿瘤化疗可实现成功治疗。