阿尔茨海默病中的单光子发射计算机断层扫描：与双侧顶颞叶灌注不足相关的特征
SPECT in Alzheimer's disease: features associated with bilateral parietotemporal hypoperfusion.
作者信息
Nitrini R, Buchpiguel C A, Caramelli P, Bahia V S, Mathias S C, Nascimento C M, Degenszajn J, Caixeta L
机构信息
Department of Neurology, University of São Paulo School of Medicine, Brazil.
出版信息
Acta Neurol Scand. 2000 Mar;101(3):172-6. doi: 10.1034/j.1600-0404.2000.101003172.x.
OBJECTIVE
To investigate why bilateral parietotemporal hypoperfusion, the typical SPECT pattern of Alzheimer's disease (AD), occurs in some but not in all patients with probable AD.
METHODS
We reviewed the SPECT scans of 220 patients presenting with cognitive impairment. Among them, 104 patients fulfilled NINCDS-ADRDA criteria for probable AD, 48 (32 women) with early onset (before age of 65) and 56 (40 women) with late onset of the symptoms. Dementia severity was assessed by the Mini-Mental State Examination. The SPECT scans were classified by visual inspection blind to clinical diagnoses.
RESULTS
Bilateral parietotemporal hypoperfusion was more frequent in patients with severe AD, in those with early onset of the symptoms, and in men. Duration of symptoms, type of gamma-camera or radiopharmaceutical agent used were not associated with this SPECT pattern.
CONCLUSION
These findings may be useful in the clinical setting and point to heterogeneity of AD according to age at onset.
目的
探究为何双侧顶颞叶灌注不足（阿尔茨海默病（AD）典型的单光子发射计算机断层扫描（SPECT）表现）在部分可能患有AD的患者中出现，而不是在所有此类患者中出现。
方法
我们回顾了220例有认知障碍患者的SPECT扫描结果。其中，104例患者符合NINCDS-ADRDA可能AD的标准，48例（32例女性）为早发型（65岁之前），56例（40例女性）为晚发型。痴呆严重程度通过简易精神状态检查表评估。SPECT扫描结果通过对临床诊断不知情的视觉检查进行分类。
结果
双侧顶颞叶灌注不足在重度AD患者、症状早发患者以及男性中更为常见。症状持续时间、所使用的γ相机类型或放射性药物与这种SPECT表现无关。
结论
这些发现可能在临床环境中有用，并表明AD根据发病年龄存在异质性。
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