使用99mTc-HM-PAO的单光子发射计算机断层扫描在阿尔茨海默病常规评估中的应用

Single photon emission computed tomography using 99mTc-HM-PAO in the routine evaluation of Alzheimer's disease.

作者信息

Hurwitz T A, Ammann W, Chu D, Clark C, Holden J, Brownstone R

机构信息

Department of Psychiatry, University of British Columbia, Vancouver, Canada.

出版信息

Can J Neurol Sci. 1991 Feb;18(1):59-62. doi: 10.1017/s0317167100031292.

DOI:10.1017/s0317167100031292

PMID:2036616

Abstract

Regional cerebral blood flow was studied in 7 patients with clinically suspected Alzheimer's disease and 10 normal controls by single photon computed emission tomography (SPECT) using HM-PAO. All patients with Alzheimer's disease and no controls had parietal lobe hypoperfusion which was usually bilateral. In patients with more severe dementia hypoperfusion extended into the frontal lobes. Parietal lobe hypoperfusion corresponds to parietal lobe degeneration which is the one of the first neocortical regions to show the typical degenerative changes of Alzheimer's disease. SPECT with HM-PAO is a non-invasive investigation available in most nuclear medicine departments and complements existing tests in the routine evaluation of patients presenting with dementia.

摘要

通过使用六甲基丙烯胺氧（HM-PAO）的单光子计算机发射断层扫描（SPECT），对7例临床疑似阿尔茨海默病患者和10名正常对照者的局部脑血流量进行了研究。所有阿尔茨海默病患者而非对照者均存在顶叶灌注不足，且通常为双侧性。在痴呆程度较重的患者中，灌注不足扩展至额叶。顶叶灌注不足与顶叶变性相对应，顶叶是最早出现阿尔茨海默病典型退行性变化的新皮质区域之一。使用HM-PAO的SPECT是一种大多数核医学科室都可进行的非侵入性检查，可在痴呆患者的常规评估中补充现有检查。