Verheul R, Kranzler H R, Poling J, Tennen H, Ball S, Rounsaville B J
Amsterdam Institute for Addiction Research, University of Amsterdam, The Netherlands.
Acta Psychiatr Scand. 2000 Feb;101(2):110-8. doi: 10.1034/j.1600-0447.2000.90050.x.
This study examined the co-occurrence of anxiety/mood and personality disorders (PDs) in substance abusers, the impact of anxiety/ mood disorders on the symptom profiles of PDs, and the impact of anxiety/mood disorders and PDs on pre-treatment status.
Current anxiety/mood disorders and PDs and pre-treatment status were assessed using semi-structured interviews in 370 treated substance abusers.
Anxiety/mood disorders and PDs frequently co-occurred, with the overall pattern of associations being non-specific. The strongest associations were of social phobia with avoidant and schizotypal PD, and of major depression with borderline PD. However, symptom profiles of PDs were not associated with anxiety/mood disorders. Finally, anxiety/mood disorders and PDs were both independently and differentially associated with poor pre-treatment characteristics.
The findings suggest the clinical importance of obtaining both Axis I and Axis II diagnoses in treated substance abusers, and highlight the distinctiveness of the Axis I and Axis II disorders.
本研究考察了物质滥用者中焦虑/情绪障碍与人格障碍（PDs）的共病情况、焦虑/情绪障碍对人格障碍症状特征的影响，以及焦虑/情绪障碍和人格障碍对治疗前状态的影响。
通过半结构化访谈对370名接受治疗的物质滥用者的当前焦虑/情绪障碍、人格障碍及治疗前状态进行评估。
焦虑/情绪障碍和人格障碍经常共病，总体关联模式不具特异性。最强的关联是社交恐惧症与回避型及分裂型人格障碍，以及重度抑郁症与边缘型人格障碍。然而，人格障碍的症状特征与焦虑/情绪障碍无关。最后，焦虑/情绪障碍和人格障碍均与治疗前的不良特征独立且有差异地相关。
研究结果表明在接受治疗的物质滥用者中获得轴I和轴II诊断的临床重要性，并突出了轴I和轴II障碍的独特性。
