白细胞介素-18在诱导针对重组抗原的强烈1型辅助性T细胞（Th1）免疫反应中增强了白细胞介素-12的佐剂特性。
IL-18 potentiates the adjuvant properties of IL-12 in the induction of a strong Th1 type immune response against a recombinant antigen.
作者信息
Eberl M, Beck E, Coulson P S, Okamura H, Wilson R A, Mountford A P
机构信息
Department of Biology, University of York, York, UK.
出版信息
Vaccine. 2000 Apr 3;18(19):2002-8. doi: 10.1016/s0264-410x(99)00532-0.
Due to the synergistic effects of IL-12 and IL-18, and to their importance in establishing a Th1 type immune response, we investigated the potential of a combined administration of both cytokines as an adjuvant for recombinant antigens. As a model system, we used a schistosome T cell antigen recently identified in our group. By co-adsorption of this antigen on alum in the presence of IL-12 and IL-18, we demonstrate that IL-18 enhances the effects of IL-12 in inducing an antigen-specific Th1 type CD4(+) T cell response as well as high titres of IgG1, IgG2a, and IgG2b antibodies.
由于白细胞介素-12（IL-12）和白细胞介素-18（IL-18）的协同作用，以及它们在建立Th1型免疫反应中的重要性，我们研究了联合给予这两种细胞因子作为重组抗原佐剂的潜力。作为模型系统，我们使用了最近在我们小组中鉴定出的一种血吸虫T细胞抗原。通过在IL-12和IL-18存在的情况下将该抗原与明矾共吸附，我们证明IL-18在诱导抗原特异性Th1型CD4(+) T细胞反应以及高滴度的IgG1、IgG2a和IgG2b抗体方面增强了IL-12的作用。
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