Ivanov Konstantin, Garanina Ekaterina, Rizvanov Albert, Khaiboullina Svetlana
Kazan Federal University, 420008 Kazan, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Pathogens. 2020 Mar 30;9(4):252. doi: 10.3390/pathogens9040252.
Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. Inflammasome activation leads to the secretion of pro-inflammatory cytokines such as IL-1β and IL-18, which stimulate the adaptive immune system. Inflammasomes activators can be used as adjuvants to provide and maintain the strength of the immune response. This review is focused on the mechanisms of action and the effects of adjuvants on inflammasomes. The therapeutic and prophylaxis significance of inflammasomes in infectious diseases is also discussed.
炎性小体是固有免疫系统的重要组成部分。它们对于针对传染病产生健康的免疫反应至关重要。炎性小体激活会导致促炎细胞因子如白细胞介素-1β和白细胞介素-18的分泌，从而刺激适应性免疫系统。炎性小体激活剂可作为佐剂来提供并维持免疫反应的强度。本综述聚焦于佐剂对炎性小体的作用机制及影响。还讨论了炎性小体在传染病中的治疗和预防意义。
