Knöll A, Hottenträger B, Kainz J, Bretschneider B, Jilg W
Institute for Medical Microbiology and Hygiene, University of Regensburg, 93042, Regensburg, Germany.
Vaccine. 2000 Apr 3;18(19):2029-32. doi: 10.1016/s0264-410x(99)00524-1.
Combining several vaccines in a single formulation can change the potency of the vaccine antigens. Previous studies suggested a higher immunogenicity of a new combined hepatitis A and B vaccine compared with the monovalent hepatitis B vaccine. We investigated the immune response to hepatitis B surface antigen 1 month after the third vaccine dose in 282 healthy adults who had received either a monovalent hepatitis B vaccine (n=148) or the combined hepatitis A/B vaccine (n=134). A slight trend towards higher geometric mean titres of anti HBs was found at this point in time in the group immunised with the combined vaccine, especially in the few vaccinees with preexisting antibodies against hepatitis A virus. However none of these differences was statistically significant, arguing against an advantage of the combined vaccine regarding hepatitis B immunisation.
将几种疫苗组合在单一制剂中可能会改变疫苗抗原的效力。先前的研究表明，与单价乙型肝炎疫苗相比，新的甲型和乙型肝炎联合疫苗具有更高的免疫原性。我们调查了282名健康成年人在接种第三剂疫苗1个月后对乙型肝炎表面抗原的免疫反应，这些成年人分别接种了单价乙型肝炎疫苗（n = 148）或甲型/乙型肝炎联合疫苗（n = 134）。在这个时间点，接种联合疫苗的组中抗-HBs几何平均滴度有轻微升高的趋势，特别是在少数已有抗甲型肝炎病毒抗体的接种者中。然而，这些差异均无统计学意义，这表明联合疫苗在乙型肝炎免疫方面并无优势。
