Gössner W, Hug O, Luz A, Müller W A
Recent Results Cancer Res. 1976(54):36-49. doi: 10.1007/978-3-642-80997-2_4.
Single and repeated applications of 224Ra and single applications of 227Th to more than 600 female NMRI mice 3 - 4 weeks old, and to male NMRI mice have led to a high rate of osteosarcomas. Tumor incidence is dose-related. 227Th is more carcinogenic than 224Ra which induced the highest tumor incidence of 60% after a single injection of 5 muCi per Kg body weight or more. Repeated injections of 224Ra to female mice yielded a tumor incidence of up to 92%. Most of these osteosarcomas consist of well-differentiated bone-forming osteoplastic tissue. Half of the tumors occurred in the spine, particularly in the lumbar region. In protraction experiments, multifocal osteosarcomas have been observed. Less than 10% of the mice with osteosarcoma had developed metastases in lung, spleen, liver, and kidney. The possible mechanisms of the protraction effect are discussed.
对600多只3 - 4周龄的雌性NMRI小鼠以及雄性NMRI小鼠单次和重复应用224Ra，单次应用227Th，已导致骨肉瘤的高发生率。肿瘤发生率与剂量相关。227Th比224Ra更具致癌性，单次注射每千克体重5微居里或更高剂量的224Ra后，其诱导的最高肿瘤发生率为60%。对雌性小鼠重复注射224Ra，肿瘤发生率高达92%。这些骨肉瘤大多由分化良好的成骨骨形成组织构成。一半的肿瘤发生在脊柱，尤其是腰椎区域。在延长实验中，已观察到多灶性骨肉瘤。患骨肉瘤的小鼠中不到10%在肺、脾、肝和肾发生了转移。讨论了延长效应的可能机制。
