Bräunlich H, Splinter F K
Acta Biol Med Ger. 1976;35(6):793-8.
The renal excretion of sulfaclomide, sulfamerazine and sulfamethoxypyridazine is delayed by increased fluid application in rats. The simultaneous administration of sulfonamides and ammonium chloride or sodium hydrogen carbonate causes, respectively, retardation and acceleration of renal sulfonamide excretion which is consistent with the change in urinary pH value. The retarded renal sulfonamide excretion with increasing diuresis is explained by the ensuing change in the urinary pH value. For clinical uses, a speedy renal excretion of long-time sulfonamides by increased diuresis can be expected only if alkalization of the urine is achieved at the same time.
在大鼠中，增加补液量会延迟磺胺氯哒嗪、磺胺甲基嘧啶和磺胺甲氧嗪的肾脏排泄。同时给予磺胺类药物和氯化铵或碳酸氢钠，分别会导致肾脏磺胺类药物排泄延迟和加速，这与尿液pH值的变化一致。随着利尿增加，肾脏磺胺类药物排泄延迟是由随之而来的尿液pH值变化所解释的。对于临床应用而言，只有同时实现尿液碱化，才有望通过增加利尿来促使长效磺胺类药物快速经肾脏排泄。
