Bräunlich H
Acta Biol Med Ger. 1975;34(6):1083-5.
The excretion velocity of sulfamerazine is very slow, caused by a high reabsortion rate in renal tubuli. An increased diuresis by i.p. administration of saline or p.o. load with water has no effect on the sulfamerazine excretion velocity. The enhanced diuresis is accompanied by a decrease of the urine pH-value and consequently by a decreased dissociation rate of sulfamerazine.
磺胺甲基嘧啶的排泄速度非常缓慢，这是由肾小管中高重吸收率所致。腹腔注射生理盐水或经口饮水负荷增加尿量，对磺胺甲基嘧啶的排泄速度没有影响。尿量增加伴随着尿液pH值降低，进而导致磺胺甲基嘧啶的解离率下降。
