Ward T, Powell R M, Chaudhry Y, Meredith J, Almond J W, Kraus W, Nelsen-Salz B, Eggers H J, Evans D J
Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 5JR, United Kingdom.
J Virol. 2000 Apr;74(7):3410-2. doi: 10.1128/jvi.74.7.3410-3412.2000.
Picornavirus infection requires virus uncoating, associated with the production of 135S "A" particles and 80S empty particles from 160S mature virions, to release the RNA genome into the cell cytoplasm. Normal albumin inhibits this process. We now show that when depleted of fatty acids, albumin induces the formation of echovirus A particles.
小核糖核酸病毒感染需要病毒脱壳，这与从160S成熟病毒粒子产生135S“A”粒子和80S空粒子相关，从而将RNA基因组释放到细胞质中。正常白蛋白会抑制这一过程。我们现在表明，当去除脂肪酸后，白蛋白会诱导埃可病毒A粒子的形成。
