博尔纳病病毒10千道尔顿蛋白上P蛋白结合结构域的特征分析
Characterization of the P protein-binding domain on the 10-kilodalton protein of Borna disease virus.
作者信息
Malik T H, Kishi M, Lai P K
机构信息
Department of Biosciences, Salem-Teikyo University, Salem, West Virginia 26426-0500, USA.
出版信息
J Virol. 2000 Apr;74(7):3413-7. doi: 10.1128/jvi.74.7.3413-3417.2000.
Abstract
The Borna disease virus (BDV) is the prototype member of the Bornaviridae, and it replicates in the cell nucleus. The BDV p24P and p40N proteins carry nuclear localization signals (NLS) and are found in the nuclei of infected cells. The BDV p10 protein does not have an NLS, but it binds with P and/or N and is translocated to the nucleus. Hence, p10 may play a role in the replication of BDV in the cell nucleus. Here, we show that the P-binding domain is located in the N terminus of p10 and that S(3) and L(16) are important for the interaction.
摘要
博尔纳病病毒（BDV）是博尔纳病毒科的原型成员，它在细胞核中复制。BDV的p24P和p40N蛋白带有核定位信号（NLS），并存在于受感染细胞的细胞核中。BDV的p10蛋白没有NLS，但它与P和/或N结合并被转运到细胞核。因此，p10可能在BDV在细胞核中的复制中发挥作用。在此，我们表明P结合域位于p10的N末端，并且S(3)和L(16)对于这种相互作用很重要。
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