Briese T, de la Torre J C, Lewis A, Ludwig H, Lipkin W I
Institute of Virology, Free University of Berlin, Federal Republic of Germany.
Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11486-9. doi: 10.1073/pnas.89.23.11486.
Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Borna disease virus is a single-stranded RNA virus. We describe here a method for isolation of viral particles that has allowed definitive identification of the genome as containing a negative-polarity RNA. Further, we show that the viral mRNAs are transcribed in the nucleus.
博尔纳病病毒是一种未分类的传染性病原体，可在多种动物宿主中引起免疫介导的神经疾病，并且可能与人的某些神经精神疾病的发病机制有关。最初的报告表明，博尔纳病病毒是一种单链RNA病毒。我们在此描述一种分离病毒颗粒的方法，该方法能够明确鉴定出其基因组包含负链RNA。此外，我们还表明病毒mRNA在细胞核中进行转录。
