Huttunen J K, Mäkinen K K, Scheinin A
Acta Odontol Scand. 1976;34(6):345-51. doi: 10.3109/00016357609004646.
The effect of chronic consumption of sucrose, xylitol and fructose on lipid, carbohydrate and urate metabolism was studied in conjunction with a clinical trial on the effects of these sugars on dental caries. No consistent differences were found in serum triglycerides, glucose, insulin, urate, lactate, or pyruvate concentrations or in the urinary excretion of urate between the groups using sucrose, fructose or xylitol as the dietary sweetener. Serum cholesterol tended to be lower in the fructose than in the xylitol group, but the difference disappeared when subjects with initial high serum cholesterol in the baseline examination were excluded from the calculations. The results suggest that the effects of peroral fructose and xylitol on the metabolic parameters studied in this investigation do not differ from that of sucrose.
结合一项关于这些糖类对龋齿影响的临床试验，研究了长期食用蔗糖、木糖醇和果糖对脂质、碳水化合物及尿酸代谢的影响。在以蔗糖、果糖或木糖醇作为膳食甜味剂的各组之间，血清甘油三酯、葡萄糖、胰岛素、尿酸、乳酸或丙酮酸浓度，以及尿酸的尿排泄量均未发现一致的差异。果糖组的血清胆固醇往往低于木糖醇组，但在计算时排除基线检查时初始血清胆固醇较高的受试者后，这种差异消失了。结果表明，口服果糖和木糖醇对本研究中所考察的代谢参数的影响与蔗糖并无不同。
