Ohara K, Isoda H, Suzuki Y, Takehara Y, Ochiai M, Takeda H, Igarashi Y, Ohara K
Department of Psychiatry, Hamamatsu University School of Medicine, Shizuoka, Japan.
Psychiatry Res. 1998 Dec 14;84(2-3):55-60. doi: 10.1016/s0925-4927(98)00050-x.
Proton magnetic resonance spectroscopy (1H-NMS) was used to examine the ratio of choline-containing compound (Cho) to creatine (Cr) in the basal ganglia. Subjects comprised 10 bipolar I affective disorder patients and 10 healthy control subjects. No significant difference was found in the Cho/Cr, N-acetyl-aspartate (NAA)/Cr, or NAA/Cho ratios between bipolar patients and control subjects. Within the bipolar group, negative correlations emerged between the NAA/Cr ratio in the right lenticular nuclei and both age at onset and age at the time of study. The results suggest that a late onset of illness and older age are associated with neuronal cell loss in the right lenticular nuclei in bipolar patients.
采用质子磁共振波谱（1H-NMS）检测基底神经节中含胆碱化合物（Cho）与肌酸（Cr）的比值。研究对象包括10例双相I型情感障碍患者和10名健康对照者。双相情感障碍患者与对照者之间的Cho/Cr、N-乙酰天门冬氨酸（NAA）/Cr或NAA/Cho比值均未发现显著差异。在双相情感障碍组中，右侧豆状核的NAA/Cr比值与发病年龄和研究时的年龄均呈负相关。结果表明，双相情感障碍患者发病较晚和年龄较大与右侧豆状核神经元细胞丢失有关。
