Department of Psychiatry, Faculty of Medicine, Pamukkale University, Denizli 20100, Turkey.
Department of Psychiatry, Antalya Training and Research Hospital, Antalya 07050, Turkey.
Neural Regen Res. 2012 Dec 25;7(36):2929-36. doi: 10.3969/j.issn.1673-5374.2012.36.011.
The aim of this study was to investigate proton magnetic resonance spectroscopy metabolite values in the medial prefrontal cortex of individuals with euthymic bipolar disorder. The subjects consisted of 15 patients with euthymic bipolar disorder type I and 15 healthy controls. We performed proton magnetic resonance spectroscopy of the bilateral medial prefrontal cortex and measured levels of N-acetyl aspartate, choline and creatine. Levels of these three metabolites in the medial prefrontal cortex were found to be lower in patients with bipolar disorder compared with healthy controls. A positive correlation was found between illness duration and choline levels in the right medial prefrontal cortex. Our study suggests that during the euthymic period, there are abnormalities in cellular energy and membrane phospholipid metabolism in the medial prefrontal cortex, and that this may impair neuronal activity and integrity.
本研究旨在探讨处于缓解期的单相双相障碍患者前额叶皮质内的质子磁共振波谱代谢物值。受试者包括 15 名处于缓解期的 I 型单相双相障碍患者和 15 名健康对照者。我们对双侧前额叶皮质进行了质子磁共振波谱分析，并测量了 N-乙酰天冬氨酸、胆碱和肌酸的水平。结果发现，双相障碍患者前额叶皮质内这三种代谢物的水平均低于健康对照组。右侧前额叶皮质内胆碱水平与疾病持续时间呈正相关。我们的研究提示，在缓解期，前额叶皮质内存在细胞能量和膜磷脂代谢异常，这可能损害神经元的活动和完整性。
