Karoumi B, Ventre-Dominey J, Vighetto A, Dalery J, d'Amato T
Institut de Psychopathologie Cognitive et Neurobiologique, Jeune Equipe 1882 (Université Lyon I), Hôpital du Vinatier, Lyon-Bron, France.
Psychiatry Res. 1998 Jan 16;77(1):9-19. doi: 10.1016/s0165-1781(97)00126-1.
The nature of saccadic abnormalities in schizophrenia was investigated in three different paradigms: (1) the visually guided saccade; (2) the antisaccade; and (3) the remembered saccade paradigm. Subjects comprised 14 schizophrenic patients and 14 normal volunteers. Deficits in the schizophrenic group were observed in the antisaccade and remembered saccade tasks, both of which were characterized by increased latency and reduced gain. Moreover, in the antisaccade task, schizophrenic patients showed an increased number of errors compared with control subjects. Saccadic abnormalities in the patients were correlated with impaired performance on the Wisconsin Card Sorting Test. These data suggest that schizophrenic patients have difficulty in inhibiting reflexive saccades and in producing voluntary saccades. The implications of these findings for a prefrontal cortex dysfunction involved in oculomotor control in schizophrenia are discussed.
（1）视觉引导扫视；（2）反扫视；以及（3）记忆扫视范式。研究对象包括14名精神分裂症患者和14名正常志愿者。在反扫视和记忆扫视任务中观察到精神分裂症组存在缺陷，这两项任务的特点都是潜伏期延长和增益降低。此外，在反扫视任务中，与对照组相比，精神分裂症患者的错误数量增加。患者的扫视异常与威斯康星卡片分类测验的表现受损相关。这些数据表明，精神分裂症患者在抑制反射性扫视和产生自主性扫视方面存在困难。讨论了这些发现对精神分裂症眼动控制中涉及的前额叶皮质功能障碍的意义。
